The Biological Consequences of Age-related Clonal Hematopoiesis

$4.09M USD

Funder	NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Recipient Organization	Johns Hopkins University
Country	United States
Start Date	Feb 10, 2021
End Date	Jan 31, 2026
Duration	1,816 days
Number of Grantees	1
Roles	Principal Investigator
Data Source	NIH (US)
Grant ID	`10570931`

Grant Description

Clonal hematopoiesis of indeterminate potential (CHIP) defined as acquisition of somatic mutations in hematopoietic cells is a common age-related condition. The prevalence of CHIP exceeds 12% over all age groups and nearly 50% for subjects older than 85-years. Since somatic mutations frequently affect putative

cancer drivers the malignant transformation to myelodysplasia or leukemia is an obvious concern. Even though CHIP is relatively common, the risk of progression to clinically apparent disease is low (