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Active RESEARCH CENTERS NIH (US)

Computational Support for All Echinobase Objectives


Funder EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
Recipient Organization Carnegie-Mellon University
Country United States
Start Date Sep 22, 2023
End Date Jun 30, 2028
Duration 1,743 days
Number of Grantees 1
Roles Principal Investigator
Data Source NIH (US)
Grant ID 10715582
Grant Description

SUMMARY COMPUTATIONAL 1 Computational Support for all Echinobase Objectives The goal of the Computation component is to keep Echinobase operational, reliable, and responsive, to maintain and upgrade the hardware, cloud, infrastructure, software and systems necessary for peak performance and to develop and support the proposed improvements described in other sections of this

application. Knowledgebases like Echinobase must integrate and process a diverse array of data and provide users with tools and interfaces to query and explore its content. These are all computational processes. In addition, Echinobase must interface with external databases and resources (NCBI, the AGR, publishers) to

synchronize content and to provide annotated echinoderm data. Although invisible to the user, there is a considerable amount of computing that occurs behind the scenes every time a researcher uses Echinobase. Echinobase is a complex computing environment consisting of multiple, separate databases, many different

software applications, user and curator web interfaces, and many automated data exchange pipelines. To ensure stability and enhance performance, tool sets are isolated on their own virtual machines (VMs) - we currently run ~10 VMs in our private cloud - and we constantly monitor, test, maintain, and fix bugs to keep it all

running smoothly. Each time new software is implemented, we test it on isolated VMs, then optimize and integrate it with existing systems. Many of these systems, including the database and the web application server, will be migrated to new systems in the new cycle, along with a move from private cloud to the public

cloud. All of this activity is contained within the Computation component and is paramount to achieving our overall project goals. In this component, we describe the computing work needed to maintain current functionality, generate custom content and the resources necessary to implement expansions and

improvements over the next award cycle. Aim 1. Migrate software stack to open source systems and implement core features on the commercial cloud Aim 2. Maintain and expand computation of Echinobase content Aim 3. Manage and monitor networking and systems

All Grantees

Carnegie-Mellon University

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