Core A Administrative Core

SUMMARY The Administrative Core (Core A) is an essential core that will organize, coordinate, and oversee, and support the three Projects, and the other two Cores of this PPG. The Core is co-led by George F. Murphy, MD, and Markus H. Frank, MD, whose collaborative history, complementary expertise, and delegation of Core A

responsibilities are in keeping with the multi-PI infrastructure of this PPG. In addition to the institutional resources and administrative support structures available to Drs. Murphy and Frank through BWH and BCH, respectively. The overarching goals of the Core are summarized in the categories of i) communication and data sharing; ii)

oversight and guidance; and iii) administrative support, and may be briefly described as follows: 1) Implement and oversee a web-based mechanism for data sharing. This relates to the establishment and maintenance of a web-based, secure site for data sharing consisting of three complementary layers of DropBox,

Harvard Dataverse and Basecamp, that permit secure access from any location or device with internet capabilities. In addition, it recognizes the ongoing responsibility of Core A CL’s to regularly monitor data accrual and overall PPG progress in a manner that data is rapidly and efficiently shared with the scientific community

through web-based technology and an ongoing commitment to publish appropriate findings in open-access journals, or by utilizing public relations resources at the participating institutions for data sharing with the lay public. 2) Monitor and maximize Project progress, inter-Project/Core synergies, and Core utilization. This includes the

creation of mutually-agreed upon milestones to be achieved among Projects and Cores, their centralized monitoring, and maintenance of a continuous feedback loop involving Projects/Cores and Core A to maximize project momentum, intercept and address any problems that may inhibit or delay progress, monitor aspects

related to reproducibility, and insure that appropriate deliverables are attained in a focused manner that insures translational relevance and eventual clinical application. This aim is structured on regular (monthly) scheduled interactions involving all Project and Core leads during which progress may be assessed and maximized.

3) Provide general administrative support for the PPG. This includes a) the scheduling of monthly meetings; b) establishment and orchestration of periodic meetings with an External Advisory Board (EAB) to review progress and assist in planning; c) conflict mediation and resolution; d) preparation of non-competitive renewal

applications and progress reports; e) budgetary management; f) coordination and facilitation of institutional approvals; g) manuscript submission to PubMed Central; and management of new intellectual property created from the grant, including preparation and filing of new invention disclosures to OTD).