An Enhanced Package of Care to Reduce Mortality in Persons with Advanced HIV Disease

$6.19M USD

Funder	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Recipient Organization	University of Minnesota
Country	United States
Start Date	Aug 23, 2021
End Date	Jul 31, 2026
Duration	1,803 days
Number of Grantees	1
Roles	Principal Investigator
Data Source	NIH (US)
Grant ID	`10896964`

Grant Description

Antiretroviral therapy (ART) is recommended for all people living with HIV (PLWH) – regardless of their CD4

cell count – to improve survival and reduce transmission. This “treat-all” approach benefits PLWH overall, but

also confers a risk of unmasking immune reconstitution inflammatory syndrome (IRIS) and death, particularly

for the 30-40% of people who present with advanced HIV disease (CD4 count 200 of