The Center for Clinical and Translational Research at the University of South Carolina (CLINTRUSC)

Summary The incidence of chronic diseases such as metabolic disease, cardiovascular disease, cancer, neurodegenerative disease remain persistently high in South Carolina and are disproportionally greater in the central region of the state-called the Midlands. The overarching goal of this Center for Translational Research

development (CTR-D) program is to address this unmet need by building a sustainable foundation of clinical and translational research capacity at the University of South Carolina (USC) which is geographically positioned in the middle of the state (Midlands), namely the Center for Clinical and Translational Research at USC-

CLINTRUSC. We will leverage existing clinical/translational research expertise within the USC School of Medicine, nationally recognized health science research within the USC School of Public Health, the School of Pharmacy, College of Nursing and the School of Social Work, which will allow us to tap into an important research

work force that extends beyond the usual confines of academic medicine-based clinical trial infrastructure. This also will allow us to engage meaningfully with high-risk communities that may be inaccessible or resistant to more conventional approaches. Moreover, we will engage our health systems partners; Prisma Health (the

largest health care provider in the state) and the Veterans Administration (VA) Health System to develop a centralized, cohesive approach to perform clinical and translational research throughout the Midlands of South Carolina. The CLINTRUSC program will develop the 5 essential cores required for a CTR-D which will result for

the first time at USC, a cohesive infrastructure to quickly deploy clinical/translational research projects within the Midlands with a particular focus on engaging vulnerable patient populations (underserved, veterans).