Interaction between sex steroids, physical exercise and metabolism in female reproduction and health

Reproductive dysfunction is common in women with energy deficiency and strenuous exercise, and in those with hyperandrogenism and obesity. Hyperandrogenism can also be beneficial for physical performance.

There is a need for improved diagnostics and treatment of premature ovarian insufficiency (POI) and disorders of sex development (DSD).

The aims of this translational project is to: a) elucidate the role of increased testosterone and degree of androgen receptor activity for athletic performance, reproduction and health; b) explore cell-autonomous circadian clocks as novel mechanisms and treatments of reproductive-metabolic dysfunction in PCOS; c) develop new treatment options to restore fertility in women with functional hypothalamic amenorrhea and POI.

A randomized study evaluates the effect of testosterone supplementation on physical performance, menstrual function and health.

A method for quantification of androgen receptor activity in vivo is developed to characterize functional consequences of different mutations leading to DSD.

Circadian oscillations in gene expression in peripheral blood and target tissues in PCOS are investigated by qRT-PCRs and RNA FISH.

In clinical trials, we are evaluating treatment effects of diet and lifestyle intervention, metformin and immunomodulatory therapy on reproductive function in different patient populations. The anticipated outcome of the project is improved fertility and metabolic health in women with reproductive disorders.