Mapping the formation of reactive oxygen species (ROS) from combustion and traffic related particulate air pollution

Air pollution and Particulate Matter (PM) is a global health concern. However, there is incomplete knowledge on relationships between sources, particle properties and health impacts.

Particle-induced formation of reactive oxygen species (ROS) induces oxidative stress and is suggested as a key mechanism for health-effects from exposure to PM. However, relationships between ROS formation and particle properties, components and formation remain largely unclear.

This project aims to bridge this gap by an interdisciplinary collaboration with the National Center for the Working Environment in Denmark.The project is focused on combustion and traffic aerosols.

Model particles and ambient-relevant diesel engine, biomass combustion, and wear particles will be systematically generated in experiments designed to control combustion conditions and the mechanical generation of wear particles.The experiments are conducted with the aim to develop a new framework that links particle properties and sources with ROS formation.

This framework will be evaluated with genotoxicity as endpoint, and employed to assess the toxicity of different ambient particles.A reference group composed by epidemiologists and environmental experts within transportation, local and national authorities has been formed.

This serves to provide guidance for more effective mitigation measures and energy-related decisions for the sustainable development of cities, the transport sector, and residential wood combustion.