Novel innovative techniques for prevention of hypoxia during anesthesia - Oxygenation before and during anesthesia using high-flow nasal oxygen - THRIVE

The overall aim of this project is to generate novel approaches for prevention of acute hypoxia in the perioperative period.

Novel technology for preoxygenation and oxygenation will be evaluated in clinical trials, state-of-the-art patient-centred physiological monitoring and   advanced mechanistical large animal experimental studies. Yearly, 10% of the population go through surgery.

Hypoxia remains the main ultimate cause of anesthesia-related death and morbidity and most of these events occurs during induction of anesthesia.In this project, we will in a series of patient studies evaluate the effects and mechanisms for novel perioperative approaches to preoxygenation and oxygenation using high-flow nasal oxygenIn addition, in a large animal model the mechanisms for oxygenation and gas exchange using high-flow nasal oxygenation during apnea will be investigated as well as the effect on the respiratory and cardiovascular system, and finally during prolonged apnea.To summarize, this project is based on a novel technology for oxygenation that dramatically can change current practice by eliminating most of the acute hypoxic events.

We have recently published promising studies within the field of both preoxygenation and apneic oxygenation.

The results has a potential to become a game changer in the field of anesthesia and will serve as a basis for a safer perioperative patient management, to improve quality of care and reduce the costs, with implementation within the coming years.