Targeting the growth hormone receptor for novel and personalized cancer therapeutics

Purpose and goal: ** Denna text är maskinöversatt **

The purpose of the project was to develop new treatment against colon cancer. UU purpose of participating in the project to contribute to the development of cancer treatment and, in connection with this, to be able to develop new tools and methods for research into tumor diseases. IVRS focused on establishing downregulation of the GHR receptor in human colon cancer cells for in vivo testing and identification of new drug candidates.

Expected results and effects: ** Denna text är maskinöversatt **

New methods to be able to study drug effects in tumor cells have been developed and evaluated by UU within the framework of the project. Since no drug candidate was generated by the project, we have not been able to explore the mechanism of action. IVRS can use the newly established cells and the animal model to create new collaborations with national and international partners to strengthen the company´s market position and to be able to supplement its service offering with new customer-adapted services to meet identified future needs of customers.

Approach and implementation: ** Denna text är maskinöversatt **

The consortium met via teleconferences twice per six months. Since the remaining project parties are natives of the Netherlands, the contacts between them were naturally more frequent. However, it did not affect UU or IVRS planning to a greater extent because no resources apart from access to substances were required to be able to carry out the mission within the respective WP.