Prototyping and Preclinical Evaluations of Antibiotic-free Dendritic Hydrogels Targeting Drug-Resistant Skin Pathogens

The overuse and misuse of traditional antibiotics contributes to the alarming evolution of antimicrobial resistance.

Our group’s research on the development of antibiotic-free antibacterial dendritic hydrogels to combat drug resistant bacteria has shown promise in addressing existing multidrug resistant bacteria without suffering from antimicrobial resistance, even after multiple treatments.

Importantly, we not only focus on the antibacterial performance of the materials, but also on their immunomodulation effects on human cells.

The main goals of this project are 1) develop new methodologies and novel dendritic polymeric materials with broad-spectrum antibacterial activity; 2) treat existing drug resistant bacteria and prevent the development of resistance towards our materials; 3) optimize the polymeric materials with favourable properties such as tuneable degradation rates consistent with wound healing processes, and mechanical properties that are comparable to human tissues; 4) verify the safety and anti-infection performance of our materials in an in vivo animal model; and 5) perform safety testing to show biocompatibility according to ISO 10993 and fulfil the new Medical Directive Regulation (MDR) requirements for a medical device to be used in clinic.

The outcomes of this project will be better alternatives for combating infections caused by drug resistant bacteria, and preventing the further development of drug resistance.