The complex mixture of Air Pollution and NOIse on adverse CARDIOvascular health (APNOI-CARDIO)

To meet the sustainable development goals (SDG) for “good health and well-being (SDG3)”, it is important to reduce the morbidity and mortality attributed to cardiovascular diseases (CVD) as CVD is the first cause of death globally.

It is increasingly recognized that air pollution and noise may affect CVD, providing important opportunities for community intervention by reshaping urban environments to create healthier and sustainable cities (SDG11).

However, most previous studies have reported the effect of air pollution and noise on CVD individually without accounting for the interaction/combined effect of these exposures, especially within the urban context, known as the urban exposome.

APNOI-CARDIO will evaluate the role of the complex mixture of air pollution and noise for CVD within the urban exposome. APNOI-CARDIO will exploit large resources of longitudinal studies from multiple countries in Europe.

Geographic information system technologies will be applied to estimate multiple urban environment exposures using uniform high- resolution exposure modelling across Europe.

In addition, innovative statistical approaches will be applied to evaluate how air pollution and noise interact within the urban exposome, and focusing on whether changing residential address can have a long-term impact on CVD.

This project has the unique opportunity to improve cardiovascular health linked to environmental deterioration by providing new evidence to guide better preventive policies.