Prodromal DEtErminants for PhENoconversion of idiopathic RBD to alpha-synucleinopathies

Purpose and goal:

The goal of the project is reliable prediction of phenoconversion from idiopathic REM sleep disorder to neurodegenerative diseases and personalized medicine and treatment. Expected results and effects:

Implementation of pathogenicity model to be used to predict disease development in patients. This will have important consequences on diagnosis and treatment of affected individuals. Approach and implementation:

We are going to collect patient information together with clinical partners and then define the three constituent parameters of the model. Information from patients will be used for defining in evidence-based way thresholds for the diseases. The model will be used also for prognosis. Pathogenicity model will be tested with patient cases and developed in iterative cycles.