Identification of women at increased risk of breast cancer with unfavorable prognosis

In Sweden, four women die from breast cancer every day.

The long-term objective of our research is to reduce mortality of breast cancer by improving the early detection of disease as well as by better identification of women at risk for fatal disease.

In this project, we want to acquire a comprehensive picture of the genetic and mammographic factors associated with breast cancer prognosis.

Our specific aims are: 1) Family studies on genetic determinants of prognosis; 2) Molecular studies on genetic determinants of prognosis; Aim 3) Mammographic determinants of prognosis.

In addition to investigating breast cancer recurrence and mortality as a model for fatal breast cancer, we propose to use two additional models.

First, we will study interval breast cancers, an important aggressive subgroup of breast tumors that develop during the time between screening examinations and are associated with a fatal outcome.

Second, we will study molecular subtypes of breast cancer that are associated with unfavourable prognosis.Better understanding of the role of inherited genetics is pivotal for development of personalized screening in women with high risk for aggressive breast cancer.

Furthermore, information of inherited genotype will support clinicians in optimization of hormonal therapy aiming at improved prognosis.

Clinical utilization of the mammographic density of the breast will both improve diagnostic accuracy and serve as useful indicator of early response to hormonal treatment.