DEMENTIA AND KIDNEY DISEASE: EPIDEMIOLOGICAL APPROACHES TO RISK FACTORS AND TREATMENT STRATEGIES

Dementia causes increased morbidity and mortality as well as tremendous social burden, but the treatment strategies are limited.

Dementia can be prevented, and one-third of Alzheimer’s disease cases might be attributable to potentially modifiable risk factors. Previously few studies have shown that kidney disease associated with higher prevalence of cognitive impairment.

However, there is little research on the impact of kidney disease and kidney disease management on the incidence and progression of dementia, and no research on whether dementia and dementia medications modify the progression of kidney disease.This project aims to explore the association between kidney disease and dementia, and whether kidney disease increases the risk and progression for dementia and how dementia influences the occurrence and progression of kidney disease.

We have constructed a big dataset from the >2 million citizens and incident 25,000 dementia cases with the Swedish Dementia Registry, the SCREAM kidney function biomarker registry, the Swedish Renal Registry and other Swedish health and quality registries during the last 12-years (2007-2018).

This project will contribute to our understanding of kidney disease as a modifiable factor that can influence the risk and progression of dementia.

Prevention of kidney disease and its progression can reduce the incidence of dementia, which would have an enormous societal and economic impact.