Towards a pREcision medicine Approach to Target Alzheimer´s Disease and Related Dementias (TREAT-ADRD)

Due to global aging, Alzheimer´s disease and related dementias (ADRD) are increasing in the population.

No disease-modifying treatment currently exists, but recent advances in the field suggest multifactorial processes may be at play.

Hence, it will be important to find specific disease characteristics of ADRD for prevention and treatment strategies in line with precision medicine initiatives.

Therefore, the overall aim of this 5-year project is to provide individualized risk predictions, prevention and prognosis of ADRD.In aim 1, we will use a large cohort of biobanked samples linked to Swedish registers (AMORIS), UK Biobank and the Swedish Twin Registry to identify individuals at risk of ADRD.

Variables used will be biological age, polygenic risk scores, APOE genotype, metabolic profile, cognition, age, sex and ADRD subtypes.

In aim 2, using the same data, we will apply pharmaco-epidemiology to study if individuals at risk of ADRD benefit from preventive treatment with repurposed drugs in clinical trials for ADRD.

In aim 3, we will use a clinical cohort of geriatric patients from the Stockholm region to analyze if patients with ADRD have better prognosis using these drugs.A postdoc and PhD-student will be recruited and two biostatisticians, a geriatrician, pharmaco-, and aging-epidemiologists collaborate.

The project will advance our understanding of individualized treatments for ADRD and could guide future dementia strategy regarding primary prevention.