Development of HS-mimetics against infection of pathogenic RNA viruses

The first critical event of virus infection is the attachment to host cells through interaction with the host cell receptor(s).

Apart from the ‘specific’ receptor for each virus, heparan sulfate (HS) has been reported as a co-receptor for more than 30 different virus species.

Evidences show indispensable roles of HS for SARS-CoV-2 infection, making it an attractive target for inhibition of the viral infection.Our study (VR 2020-05759) has identified novel HS-mimetics that displayed strong inhibitory activity against SARS-CoV-2 infection of cells. The priority of this study is to validate the effect of the compound in organoid and mouse models.

At the same time, the potential effects of these compounds on inhibition of other pathogenic RNA viruses will be explored.The major experiments will be performed by researchers specialized in virology with input from members in the team having expertise in HS biology.

Collaborations with international researchers with cross-disciplinary expertise are organized, including the access to BSL-3 lab. The compound is water-soluable and low toxic, having high probability of pharmaceutical development.

Positive outcome of the project is expected to be transferred to a clinical evaluation.The new knowledge obtained provides general information for developing preventive and therapeutic interventions by targeting HS-virus interaction against a broad-spectrum of RNA virus infections,