Invertebrates as vectors of antimicrobial resistance genes in urban landscapes

The spread of resistance to antimicrobial compounds among bacteria (AMR) is a major and global threat to human health, gradually impairing our capacity to treat infections with pathogenic bacteria.

The role of the environment as a source and dissemination route for AMR has only recently been acknowledged, and wastewater treatment plants (WWTP) have been identified as major potential reservoirs of AMR bacteria.

Invertebrates are abundant and prevalent in all habitats on earth and can serve as hosts to AMR bacteria and as vectors in the spread of AMR.

Despite this, we know virtually nothing about the prevalence and abundance of AMR in bacteria associated with invertebrates in nature.

The overall aim of the proposed research is to provide novel and unprecedented insight into the role of invertebrates in the spread and dynamics of AMR from WWTP. We will use a unique combination of field surveys and laboratory work. First, field efforts will allow us to document the spatial pattern of AMR in urban environments.

Second, controlled laboratory experiments will generate an understanding of the mechanisms and processes of AMR transmission both in the landscape as well as in food webs.

The proposed project will provide novel and much-needed insights into AMR dynamics in urban environments and has the potential to change the way we plan the urban landscape.