Genetic studies of prostate cancer aggressiveness and prognosis

This project aims to further advance the understanding of inherited genetic determinants for prostate cancer (PCa) aggressiveness and prognosis.

To achieve this, we will apply large-scale genomic assessments in several study populations of PCa in collaboration with international research groups.

Genome-wide association studies of individual genetic variants and combined effects of genetic risk scores will be explored. In addition, gene expression imputation to perform transcriptome-wide association studies will be applied.

Through this approach, we enable a comprehensive assessment of inherited genomic variants with respect to PCa aggressiveness and prognosis. Of importance, the clinical translatability of identified genetic markers will be investigated.

The proposed project has the possibility to contribute to considerable advancement in the understanding of the underlying etiology of the development of aggressive disease and disease progression, as well as improving the clinical management of this disease.