Endometriosis – predicting surgical outcome

The purpose of the study is to test the hypothesis that poorer pain-related outcomes after endometriosis surgery can be predicted.There is controversy regarding endometriosis surgery to treat pain and there is sparse research on predicting pain outcome after endometriosis surgery.

Endometriosis surgery is associated with a 10-50% re-operation rate at 5-years due to recurrent pain.The data will be collected from the Pain Interdisciplinary Cohort (EPPIC) registry/biobank.The aims are 1a) to validate pre-operative clinical features of central pain that predict pain-related outcomes after surgery for endometriosis pain,1b) to follow Quantitative Sensory Testing (QST) findings pre- and post-operatively to examine the impact of surgery on pain thresholds,2a) to determine whether biomarkers of in surgically-excised endometriosis tissue predict pain-related outcomes after endometriosis surgery,2b) to complete a proof-of-concept study of pre-operative uterine endometrial biopsy for neurogenesis biomarkers in uterine endometrium, in order to predict neurogenesis biomarkers in surgically-excised endometriosis tissue.The results will be translated into a decision-aid, accesible for patient and physician.

It will provide help to predict which patients would benefit from surgery in treating endometriosis, and provide further knowledge regarding the correlation between phenotyping of pain and surgical findings.