Novel Solvent-Free Excipients for Enhanced Drug Solubility and Delivery

Purpose and goal:

Emulsi Biotech aims to revolutionize oral drug delivery by introducing novel lipid mixture systems made from natural vegetable oils. Key goals include establishing solvent-free manufacturing, conducting scale-up calculations, assessing economic viability, and exploring the system as an oral drug delivery platform. Partnering with the RISE, we focus on validating our lipid mixtures as oral excipients, emphasizing sustainability, scalability, and improved medication efficacy.

Expected results and effects:

Expected effects of the project include a significant reduction in environmental impact and improved workplace safety by eliminating organic solvents. Results ought to demonstrate the scalability and economic viability of our green manufacturing process of novel lipid mixtures, validate the use of the latter mixtures in oral drug delivery, and contribute to more effective, sustainable pharmaceutical formulations.

Approach and implementation:

The project is structured into three work packages: WP1 (Emulsi Biotech AB) focuses on scaling up the enzymatic production process using Rotating Bed Reactor technology. WP2 (RISE) involves a thorough economic and environmental impact analysis based on the "SELECT" criteria and benchmarking. WP3 (collaborative efforts) evaluates lipid mixtures produced in WP1 as drug delivery system, conducting solubility studies, release rate tests, and ensuring alignment with pharmaceutical quality standards.