The hidden but very prevalent threat of combined migraine and depression: Unraveling risk factors and lowering the risk for sick leave due to co-morbidity

Research Idea and Purpose:This project explores the underexamined relationship between depression and migraine in Sweden, focusing on sleep, physical exercise, and diet.

These modifiable factors can greatly influence the severity and progression of both conditions, leading to reduced workplace productivity and impacting the national economy.

Building on our previous work, including the 2017 exercise guidelines for migraine, we aim to develop updated workplace guidelines for migraine and co-morbid depression in Sweden that integrate these factors, enhancing quality of life and reducing the socio-economic burden.Work Plan, Methods, and Project Realisation:The project begins with systematic reviews and meta-analyses to better understand the interplay between depression, migraine, and modifiable factors like physical exercise, diet, and sleep.

We will leverage and expand our collaborative network across Sweden, Norway, Iceland, and Lithuania, utilizing extensive clinical and registry data.

This effort, involving 14 leading scientists in migraine, depression, and epidemiology across Scandinavia, will form the basis for future population-based studies on migraine-depression, work situations, and guideline updates in Sweden.

Our long-term goal is to develop evidence-based workplace guidelines for Sweden, harmonized with other Nordic countries, through register and cohort-based epidemiological analyses.

Securing ethical approvals and conducting these systematic reviews and meta-analyses are the first essential steps, making the FORTE planning grant crucial for these efforts.Social Relevance and Utilization:This project fills a critical research gap in understanding migraine-depression comorbidity, particularly in relation to workplace factors.

Updated guidelines will directly improve conditions for those affected, potentially reducing absenteeism and boosting productivity.

The findings will inform much-needed national guidelines in Sweden and contribute to policy changes, benefiting the affected population. The project also aims to harmonize guidelines across Scandinavia, ensuring a broader impact.

By addressing the intersection of depression, migraine, individual modifiable aspects, and workplace factors, this research will significantly impact public health and workplace practices, improving lives and reducing socio-economic costs