Antibody Discovery and Development Against Non-Immunogenic Snake Venom Toxins

This proposal aims to ultimately reduce global levels of morbidity and mortality from snakebite envenoming by discovering and developing antibodies that can neutralize the low molecular weight snake venom toxins – key contributors to the disease.

These non-immunogenic toxins are poorly neutralized by currently available antivenoms produced by animal derived immunizations.

This proposed project will discover neutralizing antibodies through immunization experiments using rationally designed immunogens and select for high-affinity antibodies via synthetic libraries using recombinant toxins.