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One Health Alternate Antimicrobial Resistance Monitoring System (AlARMS)
| Funder | Wellcome Trust |
|---|---|
| Recipient Organization | University of Kwazulu Natal |
| Country | United Kingdom |
| Start Date | Oct 01, 2023 |
| End Date | Sep 30, 2025 |
| Duration | 730 days |
| Number of Grantees | 1 |
| Roles | Award Holder |
| Data Source | Europe PMC |
| Grant ID | 228172 |
Grant Description
Leveraging the existing wastewater surveillance infrastructure built for polio and COVID-19 in South Africa, and, using a metagenomic approach, the proposed Alternate Antimicrobial Resistance Monitoring System (AlARMS) will delineate the burden of AMR from the longitudinal surveillance of the microbiome, resistome and mobilome in multiple One Health settings, comparing and contrasting genomic data from three
Sources & References
gut microbiota of vulnerable/at- risk humans, gut microbiota of their major, intensively-produced food animal sources, and associated wastewater microbiota. AlARMS will ascertain whether AMR in wastewater is representative of AMR in the microbiota of vulnerable/at- risk human (adding a step to the sewage-clinical AMR correlation by linking population-level AMR data) and animal populations and compare this to AMR in contemporary bacterial isolates from clinical and veterinary laboratories. The project will additionally explore the correlation/association (if any) between antimicrobial use (AMU) and antimicrobial residues in wastewater. AlARMS also includes an ethnographic study to ascertain socio-behavioural drivers of AMR and uses mathematical modelling to elucidate transmission dynamics. AlARMS may serve as early-warning and a proxy for conventional AMR surveillance systems in humans, food animals and the water, sanitation and hygiene (WASH) sector.
All Grantees
University of Kwazulu Natal
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