Optogenetic modeling of a hallmark neurodegeneration pathology for mechanistic research and drug discovery.

Funder	Medical Research Council
Recipient Organization	University of Sheffield
Country	United Kingdom
Start Date	Sep 30, 2024
End Date	Sep 29, 2028
Duration	1,460 days
Number of Grantees	2
Roles	Student; Supervisor
Data Source	UKRI Gateway to Research
Grant ID	`2928896`

Grant Description

Purpose/aims: 1. Establish neuronal models with inducible optoDPR aggregation to comprehensively characterise DPR aggregation-induced neuropathology (primary supervisor).

2. Generate in vivo (Drosophila) optoDPR models to analyse behavioural, tissue and cellular phenotypes elicited by DPR aggregation (second supervisor).

3. Develop an optoDPR cellular assay for drug screening and orthogonal assays in in vivo models for small-molecule screening and validation studies (all supervisors).