Determining the role of Cyclin B2 in Genomic Stability

Funder	Medical Research Council
Recipient Organization	Institute of Cancer Research
Country	United Kingdom
Start Date	Oct 06, 2024
End Date	Oct 05, 2028
Duration	1,460 days
Number of Grantees	2
Roles	Student; Supervisor
Data Source	UKRI Gateway to Research
Grant ID	`2933546`

Grant Description

Mitosis is controlled by the major mitotic kinase CDK1 and its regulatory partner, Cyclin B. There are two B-type cyclins in vertebrate cells: Cyclins B1 and B2. Cyclin B1 is essential but the role of Cyclin B2 is controversial.

In this project we will use CRISPR/Cas9 gene editing to provide a definitive answer to the question of what role Cyclin B2 has in cell division and genome stability.