Correlate of Protection against Paratyphoid (CoP-PT)

There is a huge global burden of enteric fever which disrupts the lives of children in settings with inadequate quality water and poor sanitation and it kills.

Through our series of epidemiological studies, clinical trials (~100,000 children) and pivotal research using the typhoid controlled human infection model (CHIM) in Oxford, over 60million doses of a new typhoid vaccine has been rolled out in the past 2-years.

But Salmonella Paratyphi A, which is not covered by this vaccine, remains the cause of one third of the global burden of enteric fever each year, amounting to about 3 million cases.

Here we propose to accelerate the development of novel paratyphoid vaccines using a suite of studies to establish correlates of protection and enable bridging of data from an established paratyphoid CHIM in Oxford to natural infection and vaccination in endemic populations, and a CHIM in Pakistan.

The applicants are leading enteric fever researchers from endemic regions, UK/USA with expertise in the clinical, epidemiological, immunological (including systems serology), molecular, statistical, modelling methods required to establish correlates of protection.

Data generated through this programme are expected to be pivotal in supporting policy decisions on global licensure and policy on new vaccines against paratyphoid.