What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with non-surgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 60 years? (MOTION Trial)

£183.38M GBP

Funder	National Institute for Health and Care Research
Recipient Organization	The University of Edinburgh
Country	United Kingdom
Start Date	Aug 01, 2022
End Date	Jul 31, 2027
Duration	1,825 days
Number of Grantees	3
Roles	Co-Principal Investigator; Principal Investigator; Award Holder
Data Source	NIHR Open Data-Funded Portfolio
Grant ID	`NIHR129820`

Grant Description

BACKGROUND

Nearly 1 in 5 people >45 years in the UK suffer from pain and disability due to knee osteoarthritis (OA). This number is expected to increase dramatically over the next two decades. The James Lind Alliance designated the surgical and non-surgical options for the treatment of knee OA as a Top 10 Priority Setting Partnership in 2016. In patients >60 years with moderate-to-severe knee OA, surgery with knee replacement (partial or total) has been successful. However, in patients