The cross-national impact of discrimination on health: considering social and genetic vulnerabilities

Aim: This study will use longitudinal data from three cohort studies (n=~78,000) to assess the impact of discrimination based on a range of characteristics on mental and physical health. Objective 1: To conduct a cross-national comparison of the link between discrimination and health a.

To investigate how discrimination from different sources (e.g. sexism + ageism) affects health over time, assessing whether associations vary by country. b.

To assess the impact of repeated discrimination (based on frequency of exposure) on health over time, and to explore whether these associations vary cross-nationally. Objective 2: To assess how discrimination interacts with social and genetic vulnerabilities to influence health a.

To investigate how discrimination interacts with social vulnerability (e.g. low socioeconomic status) to influence health, assessing cross-national variations. b.

To assess how discrimination interacts with genetic vulnerability (polygenic risk scores) to influence health, across countries. Data