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99,167 grants found
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Combination nanovaccine-based immunization against influenza virus in the aged: immunity and protection
PROJECT SUMMARY / ABSTRACT Age-related defects of the immune response contribute to reduced efficacy of the influenza vaccine in older adults.Influenza A virus (IAV) infection resu...
3D Dynamic and Patient-Centered Outcomes of Facial Reanimation Surgery in Patients with Facial Paralysis
Patients with facial paralysis have an obvious facial disability that includes facial disfigurement and impairment in soft tissue movements, particularly in facial expressive behav...
The role of paracrine mTOR signaling in regulating thymus size and function
Summary T lymphocytes are critical mediators of the adaptive immune response, however, they are continuously lost throughout the lifespan, and therefore must be continuously replac...
Isolation of mononuclear propagules from coenocytic hyphae of the mucormycosis pathogen Rhizopus delemar
1.Abstract Rhizopus delemar is the leading casual-agent of mucormycosis, a life-threatening fungal infection in immunocompromised patients.Despite its clinical importance, R. delem...
Association of Staphylococcus aureus infection with autoimmunity in cystic fibrosis
Project summary The aim of this proposal is to establish a clinical association between S. aureus respiratory infection and autoimmunity in cystic fibrosis (CF). CF is a fatal gene...
The role of paracrine mTOR signaling in regulating thymus size and function
Summary T lymphocytes are critical mediators of the adaptive immune response, however, they are continuously lost throughout the lifespan, and therefore must be continuously replac...
Cell cycle proteins as key regulators of cardiac chemosensitivity
PROJECT SUMMARY Anthracycline-based chemotherapy, an effective treatment for many types of cancer, has long been associated with substantial cardiotoxicity. As one of the most comm...
Memantine augmentation of cognitive training in schizophrenia
In response to RFA-MH-18-705, this application develops and tests a novel treatment strategy for improving cognition in patients with schizophrenia (SZ), via Pharmacologic Augmenta...
Enhancing transport and delivery of ferrihydrite nanoparticles via polymer encapsulation in PFAS-contaminated sediments to simulate PFAS defluorination by Acidimicrobium sp. Strain A6
Project Summary/Abstract Per- and polyfluoroalkyl substances (PFAS) are ubiquitous in the environment and highly stable. They are present in many consumer products and over 4000 di...
Assessment of immunogenicity and antigenicity of different human cell types in natural and 3D-printed allografts
7. PROJECT SUMMARY/ABSTRACT Allograft rejection remains an issue in long term success of allotransplantation and is also likely to negatively impact the function and longevity of t...
Combination nanovaccine-based immunization against influenza virus in the aged: immunity and protection
PROJECT SUMMARY / ABSTRACT Age-related defects of the immune response contribute to reduced efficacy of the influenza vaccine in older adults. Influenza A virus (IAV) infection res...
Isolation of mononuclear propagules from coenocytic hyphae of the mucormycosis pathogen Rhizopus delemar
1. Abstract Rhizopus delemar is the leading casual-agent of mucormycosis, a life-threatening fungal infection in immunocompromised patients. Despite its clinical importance, R. del...
Association of Staphylococcus aureus infection with autoimmunity in cystic fibrosis
Project summary The aim of this proposal is to establish a clinical association between S. aureus respiratory infection and autoimmunity in cystic fibrosis (CF). CF is a fatal gene...
Flavivirus immunity in endemic and non-endemic human cohorts
PROJECT SUMMARY The global spread of the arthropod borne flaviviruses dengue (DENV1-4) and Zika (ZIKV) viruses are major global public health challenges. World health organizations...
Enhancing transport and delivery of ferrihydrite nanoparticles via polymer encapsulation in PFAS-contaminated sediments to simulate PFAS defluorination by Acidimicrobium sp. Strain A6
Project Summary/Abstract Per- and polyfluoroalkyl substances (PFAS) are ubiquitous in the environment and highly stable. They are present in many consumer products and over 4000 di...
Flavivirus immunity in endemic and non-endemic human cohorts
PROJECT SUMMARY The global spread of the arthropod borne flaviviruses dengue (DENV1-4) and Zika (ZIKV) viruses are major global public health challenges. World health organizations...
Memantine augmentation of cognitive training in schizophrenia
In response to RFA-MH-18-705, this application develops and tests a novel treatment strategy for improving cognition in patients with schizophrenia (SZ), via Pharmacologic Augmenta...
Flavivirus immunity in endemic and non-endemic human cohorts
PROJECT SUMMARY The global spread of the arthropod borne flaviviruses dengue (DENV1-4) and Zika (ZIKV) viruses are major global public health challenges. World health organizations...
Cell cycle proteins as key regulators of cardiac chemosensitivity
PROJECT SUMMARY Anthracycline-based chemotherapy, an effective treatment for many types of cancer, has long been associated with substantial cardiotoxicity. As one of the most comm...
Combination nanovaccine-based immunization against influenza virus in the aged: immunity and protection
PROJECT SUMMARY / ABSTRACT Age-related defects of the immune response contribute to reduced efficacy of the influenza vaccine in older adults. Influenza A virus (IAV) infection res...