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99,167 grants found
Showing 95,301 – 95,320 of 99,167 grants
Combination nanovaccine-based immunization against influenza virus in the aged: immunity and protection
PROJECT SUMMARY / ABSTRACT Age-related defects of the immune response contribute to reduced efficacy of the influenza vaccine in older adults. Influenza A virus (IAV) infection res...
Cell cycle proteins as key regulators of cardiac chemosensitivity
PROJECT SUMMARY Anthracycline-based chemotherapy, an effective treatment for many types of cancer, has long been associated with substantial cardiotoxicity. As one of the most comm...
Flavivirus immunity in endemic and non-endemic human cohorts
PROJECT SUMMARY The global spread of the arthropod borne flaviviruses dengue (DENV1-4) and Zika (ZIKV) viruses are major global public health challenges. World health organizations...
The Impact of Reflective Motivation on the Effect of a Shared Decision Making Intervention for Diabetes Prevention
PROJECT SUMMARY/ABSTRACT Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes (T2DM). Evidence from the Diabetes Prevention Pr...
Assessing effects of adverse Social Determinants of Health (SDOH) in TTR V122l carriers via Structured data and Natural Language Processing (NLP) extraction, a comparison
The research project has two goals. The first is to use natural language processing (NLP) to improve the identification of adverse social determinants of health (SDOH) in patients...
Investigating astrocytic RIPK3 as a driver of protective neuroinflammation during viral encephalitis
Abstract Astrocytes are versatile glial cells that regulate diverse processes in the central nervous system (CNS). Roles for astrocytes during disease are complex and include both...
Investigating astrocytic RIPK3 as a driver of protective neuroinflammation during viral encephalitis
Abstract Astrocytes are versatile glial cells that regulate diverse processes in the central nervous system (CNS). Roles for astrocytes during disease are complex and include both...
A Dyadic Approach to Perinatal Depression Treatment in Primary Care
Project Summary Ten to 20% of women have depression in the perinatal period (pregnancy through one year postpartum), especially low income racial /ethnic minority women, yet many d...
The protective role of microglia in preventing hypoxic disruption of blood-brain barrier integrity and VCID
PROJECT SUMMARY/ABSTRACT Dementia is a major health problem in the United States. Vascular contributions to cognitive impairment and dementia (VCID) is the second leading cause of...
Cellular and Molecular mechanisms of ATRA inhibition of osteoblast-induced MDS development
ABSTRACT Osteoblasts are critical components of the hematopoietic stem cell (HSC) niche that regulate hematopoiesis. More recently, they have emerged as critical regulators of the...
The role of collisions in rescuing stalled ribosomes in bacteria
PROJECT SUMMARY Translating ribosomes often encounter obstacles that stop them in their tracks: the synthesis of roughly 1 out of every 250 proteins in E. coli ends in failure. Rib...
The role of mitochondrial dynamics in diet-influenced regulation of food intake and adiposity
We have identified a role for mitochondrial dynamics (fission and fusion) in central regulation of feeding, energy- and glucose metabolism.We showed that mitochondrial fission is i...
Modeling a Neural Circuit for Flexible Control of Innate Behaviors
The adaptive control of social behaviors, such as aggression and reproduction, is a critical function of the nervous system. In the past decade, new methods for genetically targete...
A Novel Neural Mechanism that Mediates the Therapeutic Effects of Metformin
Metformin is the most prescribed first-line anti-diabetic drug. It has been widely accepted that metformin lowers blood glucose primarily by reducing glucose output in the liver, a...
The role of RGS12 in differential modulation of G protein versus beta-arrestin signaling downstream of the kappa opioid receptor
The kappa opioid receptor (KOR) helps mediate responses to stress, yet is also implicated in developing and/or maintaining health disorders of chronic pain, drug addiction, anxiety...
Dissecting the role of sialic acid and sialidase in the pathophysiology of Porphyromonas gingivalis
The overarching goal of this application is to investigate the role of sialidase and sialic acid in the keystone pathogen Porphyromonas gingivalis (Pg) and their contributions to t...
Role of Negative Elongation Factor Complex in RNA polymerase II pausing and gene transcription in Heart
PROJECT SUMMARY/ABSTRACT Congestive heart failure is one of the leading cause of morbidity and mortality in the USA and the World. However, despite the major advancements in resear...
Sequence Variants Impacting Cardiomyocyte S-phase Activity in Inbred Mice Following Injury
Numerous studies have shown that induction of cardiomyocyte cell cycle activity can have a profound beneficial impact on cardiac structure and function following myocardial infarct...
Defining cellular states of quiescence in human brain tumors
PROJECT SUMMARY The most aggressive type of brain tumor, grade IV glioma known as glioblastoma (GBM), is one of the few tumor types with both a poor outcome and minimal improvement...
Clonal hematopoiesis, inflammasomes and atherosclerosis
Project Summary/Abstract The recent CANTOS trial showed that administration of an antibody targeting IL-1b reduced coronary events, supporting the concept of anti-inflammatory ther...