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99,167 grants found
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DISSECTING THE LINK BETWEEN UREAGENESIS AND HEPATIC GLYCOGEN METABOLISM
PROJECT SUMMARY/ABSTRACT Urea cycle disorders (UCDs) are common inborn errors of hepatic metabolism. With improved therapies such as nitrogen-scavenging agents to prevent elevated...
Validation of an in vitro model of progressive fibrosis that mimics Idiopathic Pulmonary Fibrosis
Abstract We have developed a 3D bioengineered human induced pluripotent stem cell (iPSC) derived model of IPF that displays progressive fibrosis and closely phenocopies several cha...
Cortical-hippocampal brain dynamics during sleep following spatial learning in rodents modeling Tau and AB aggregation feature of Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease is devastating for individuals and society. Impaired learning and memory, particularly in the context of spatial navigation, is one of...
Neural circuit basis for neurovascular coupling
Abstract Neurovascular coupling (NVC) is the temporal relationship between neural activity and cerebral blood flow (CBF). This neural-evoked hemodynamic response is fundamental to...
BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a Trial
PROJECT SUMMARY Acute brain injuries resulting from cerebrovascular injury or trauma, such as intracerebral hemorrhage (ICH) or traumatic brain injury, are major medical problems t...
Elucidating Vascular Neuropilin 1 (NRP1) Functions in Response to Novel Interactions with Insulin Substrates
Project Summary/Abstract Obesity is emerging a major public health challenge in the United States, and around the world. It correlates with several comorbidities including, cardiov...
New mechanisms of SERCA2a regulation: role of luminal calcium
PROJECT SUMMARY/ABSTRACT SERCA2a Ca pump plays a central role in heart function. The speed at which SERCA2a removes Ca from the cytosol is the main determinant of the rate of cardi...
Genetic code expansion to enable the development of short, diverse peptide libraries
Project Summary Many intracellular cancer targets involve protein-protein interactions that are “undruggable” because the binding surfaces are too large and featureless to be block...
Small RNA Regulation in Bacteria
PROJECT SUMMARY Bacteria must sense and respond to rapidly changing and often stressful environments. Their ability to enact rapid changes in gene expression that alter cell struct...
A Shared Decision Making Intervention for Diabetes Prevention in Women with a History of Gestational Diabetes Mellitus.
PROJECT SUMMARY/ABSTRACT Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes (T2DM). Evidence from the Diabetes Prevention Pr...
Locomotor Recovery and Compensation Post-stroke
Project Summary The objective of this project is to identify the trajectory of neurological and locomotor recovery in patients early post-stroke and the biomechanical strategies us...
Pathways to improved adolescent mental health via an economic and gender equality intervention with conflict affected families
Project Summary/Abstract In the Democratic Republic of Congo, families have experienced more than two decades of violence, displacement and political instability resulting in extre...
Defining the functional organization of cerebellar output circuits that control feeding behavior
Project Summary How does the neuropathology in mouse models of Alzheimer’s disease (AD) influence the function of neural circuitry? Preliminary data demonstrates distinctions in ne...
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
Hypoplastic left heart syndrome (HLHS) is a severe type of congenital heart defects, which is characterized by the underdevelopment of left side of the heart. The clinical presenta...
Irving Estevez_Diversity Supplement: R01 NS120895
Abstract Astrocytes are versatile glial cells that regulate diverse processes in the central nervous system (CNS). Roles for astrocytes during disease are complex and include both...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...
Investigating astrocytic RIPK3 as a driver of protective neuroinflammation during viral encephalitis
Abstract Astrocytes are versatile glial cells that regulate diverse processes in the central nervous system (CNS). Roles for astrocytes during disease are complex and include both...
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
Hypoplastic left heart syndrome (HLHS) is a severe type of congenital heart defects, which is characterized by the underdevelopment of left side of the heart. The clinical presenta...
A multi-channel reconstruction toolkit for computed tomography
Abstract According to the FDA, the recent clinical availability of photon counting detector X-ray CT (PCCT) marks the “first major imaging device advancement for computed tomograph...
Defining cellular states of quiescence in human brain tumors
PROJECT SUMMARY The most aggressive type of brain tumor, grade IV glioma known as glioblastoma (GBM), is one of the few tumor types with both a poor outcome and minimal improvement...