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ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY ABSTRACT: In direct response to PA-20-071, Advanced-Stage Development and Utilization of Research Infrastructure for Interdis...
The role of mitochondrial dynamics in diet-influenced regulation of food intake and adiposity
We have identified a role for mitochondrial dynamics (fission and fusion) in central regulation of feeding, energy- and glucose metabolism.We showed that mitochondrial fission is i...
A Novel Neural Mechanism that Mediates the Therapeutic Effects of Metformin
Metformin is the most prescribed first-line anti-diabetic drug. It has been widely accepted that metformin lowers blood glucose primarily by reducing glucose output in the liver, a...
A Shared Decision Making Intervention for Diabetes Prevention in Women with a History of Gestational Diabetes Mellitus.
PROJECT SUMMARY/ABSTRACT Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes (T2DM). Evidence from the Diabetes Prevention Pr...
The role of collisions in rescuing stalled ribosomes in bacteria
PROJECT SUMMARY Translating ribosomes often encounter obstacles that stop them in their tracks: the synthesis of roughly 1 out of every 250 proteins in E. coli ends in failure. Rib...
Defining cellular states of quiescence in human brain tumors
PROJECT SUMMARY The most aggressive type of brain tumor, grade IV glioma known as glioblastoma (GBM), is one of the few tumor types with both a poor outcome and minimal improvement...
The role of RGS12 in differential modulation of G protein versus beta-arrestin signaling downstream of the kappa opioid receptor
The kappa opioid receptor (KOR) helps mediate responses to stress, yet is also implicated in developing and/or maintaining health disorders of chronic pain, drug addiction, anxiety...
Cellular and Molecular mechanisms of ATRA inhibition of osteoblast-induced MDS development
ABSTRACT Osteoblasts are critical components of the hematopoietic stem cell (HSC) niche that regulate hematopoiesis. More recently, they have emerged as critical regulators of the...
Validation of an in vitro model of progressive fibrosis that mimics Idiopathic Pulmonary Fibrosis
Abstract We have developed a 3D bioengineered human induced pluripotent stem cell (iPSC) derived model of IPF that displays progressive fibrosis and closely phenocopies several cha...
Role of Negative Elongation Factor Complex in RNA polymerase II pausing and gene transcription in Heart
PROJECT SUMMARY/ABSTRACT Congestive heart failure is one of the leading cause of morbidity and mortality in the USA and the World. However, despite the major advancements in resear...
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
Hypoplastic left heart syndrome (HLHS) is a severe type of congenital heart defects, which is characterized by the underdevelopment of left side of the heart. The clinical presenta...
Elucidating hereditary transthyretin-mediated heart failure risk using machine learning, polygenic risk and recall by genotype approaches in African ancestry individuals
PROJECT SUMMARY / ABSTRACT Mutations in the Transthyretin (TTR) gene can lead to deposition of abnormal amyloid fibrils in the myocardium, resulting in hereditary transthyretin amy...
Thermal proteome profiling for analysis of protein sequence variants in human genetic disease
Project Summary Many global proteomics studies have focused on the measurement of protein abundance and post- translational modification status as measures of cellular function. Th...
Exploiting the VISTA Pathway to Prevent Acute GVHD and Control Steroid Refractory Disease
Abstract Despite multi-drug prophylaxis, aGVHD affects 20-70% of allogeneic hematopoietic cell transplant (allo-HCT) patients. V-region Immunoglobulin-containing Suppressor of T ce...
Elucidating hereditary transthyretin-mediated heart failure risk using machine learning, polygenic risk and recall by genotype approaches in African ancestry individuals
PROJECT SUMMARY / ABSTRACT Mutations in the Transthyretin (TTR) gene can lead to deposition of abnormal amyloid fibrils in the myocardium, resulting in hereditary transthyretin amy...
New mechanisms of SERCA2a regulation: role of luminal calcium
PROJECT SUMMARY/ABSTRACT SERCA2a Ca pump plays a central role in heart function. The speed at which SERCA2a removes Ca from the cytosol is the main determinant of the rate of cardi...
Cannabis use among older adults: Potential risks and benefits to an aging population
Project Summary The population of older adults in the U.S. is increasing dramatically, doubling from 48 million to 88 million by the year 2050. As more Americans live longer, the c...
Staging Alzheimer disease with blood-based biomarkers
The brain changes of Alzheimer disease (AD) start many years before the onset of cognitive symptoms. Most models of AD propose a stepwise progression of brain pathology starting wi...
Regulation of endothelial cell specification
SUMMARY Approaches to vascular regeneration and repair require specification of endothelial cells that are competent to form functioning blood vessels. However, the process by whic...
Methodology Issues in a Tailored Light Treatment for Persons with Dementia
Project Summary/Abstract This study's principal hypothesis is that delivering a circadian-effective, tailored lighting intervention (TLI) will reveal a strong association betw...