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99,167 grants found
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An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
Hypoplastic left heart syndrome (HLHS) is a severe type of congenital heart defects, which is characterized by the underdevelopment of left side of the heart. The clinical presenta...
Using Technology to Support Care Partners for Persons with Alzheimer's Disease: Tele-STELLA
PROJECT SUMMARY The purpose of this NIH Stage 1B mixed methods study is to test the feasibility, acceptability, fidelity and efficacy of a telehealth-based intervention designed to...
Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
Project summary Patients with Alzheimer’s disease (AD) are known to have greater balance and gait impairment and double the rate of falls relative to healthy older adults (60-70% v...
Chaperome networks in Alzheimer's disease
ABSTRACT The goal of the proposed project is to address how neuronal stress triggered by amyloid-beta and tau oligomeric species induces protein connectivity dysfunctions and alter...
Gut barrier function in Alzheimer’s disease
The age-related processes that contribute to Alzheimer's disease (AD) development, particularly in the prodromal period, are incompletely understood. Age-related reduction in...
Wnt7a-Mediated Competence to Resist Osteoarthritis Progression
Abstract: Wnt7a-mediated competence to resist osteoarthritis progression Osteoarthritis (OA) is a highly prevalent and debilitating disease that currently has no effective therapy....
Opto-Electrical Cochlear Implants
Project Summary / Abstract Our goal is to develop an optical cochlear implant (oCI) that uses photons to stimulate surviving auditory neurons in severely-to-profoundly deaf. The be...
Impact of Wnt7a on Mast Cell-mediated inflammation associated with Alzheimer's Disease.
SUMMARY Alzheimer’s disease (AD) is the most common cause of dementia and disability in the elderly and the sixth leading cause of death in the U.S. Signature AD pathology includes...
Stress and Resilience in the VIP
Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and r...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
Hypoplastic left heart syndrome (HLHS) is a severe type of congenital heart defects, which is characterized by the underdevelopment of left side of the heart. The clinical presenta...
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
Hypoplastic left heart syndrome (HLHS) is a severe type of congenital heart defects, which is characterized by the underdevelopment of left side of the heart. The clinical presenta...
Cortical-hippocampal brain dynamics during sleep following spatial learning in rodents modeling Tau and AB aggregation feature of Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer?s disease is devastating for individuals and society.Impaired learning and memory, particularly in the context of spatial navigation, is one of i...
Characterization of an 18F COX-2 PET ligand for in vivo brain imaging
Alzheimer?s disease (AD) pathogenesis is associated with early neuroinflammation, which is considered to contribute to disease progression and severity.Therefore, understanding and...
PKD proteins in endothelial cells
Project Summary Endothelial cells line the wall of all blood vessels and regulate a wide variety of functions, including contractility which controls systemic blood pressure.Dysfun...
Novel regulators, components and function of endothelial diaphragms
Endothelial diaphragms are protein barriers associated with vascular endothelial subcellular structures, such as fenestrae, transendothelial channels (TEC), caveolae and vesiculo-v...
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
Hypoplastic left heart syndrome (HLHS) is a severe type of congenital heart defects, which is characterized by the underdevelopment of left side of the heart.The clinical presentat...
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
We propose to quantify aging- and AD-associated brain and blood metabolic changes through ex vivo and in vivo multimodality MR measurements in mouse models after an AD-promoting st...
Clonal hematopoiesis, inflammasomes and atherosclerosis
Project Summary/Abstract The recent CANTOS trial showed that administration of an antibody targeting IL-1b reduced coronary events, supporting the concept of anti-inflammatory ther...
Metal Exposure and Subclinical Lung Disease in Adult E-cigarette Users
E-cigarette (e-cig) use is common, particularly among adolescents and young adults, and has been associated with E-cigarette and Vaping Associated Lung Injury (EVALI).To address ma...