Browse All Grants
99,167 grants found
Showing 95,381 – 95,400 of 99,167 grants
Elucidating hereditary transthyretin-mediated heart failure risk using machine learning, polygenic risk and recall by genotype approaches in African ancestry individuals
PROJECT SUMMARY / ABSTRACT Mutations in the Transthyretin (TTR) gene can lead to deposition of abnormal amyloid fibrils in the myocardium, resulting in hereditary transthyretin amy...
Defining cellular states of quiescence in human brain tumors
PROJECT SUMMARY The most aggressive type of brain tumor, grade IV glioma known as glioblastoma (GBM), is one of the few tumor types with both a poor outcome and minimal improvement...
A Dyadic Approach to Perinatal Depression Treatment in Primary Care
Project Summary Ten to 20% of women have depression in the perinatal period (pregnancy through one year postpartum), especially low income racial /ethnic minority women, yet many d...
Clinical Neuroimmunology of Vaccines in Brain Tumors
In brain tumors like glioblastoma (GBM), failures to develop an effective vaccine and achieve immune checkpoint inhibition have been attributed to the extraordinary antigenic intra...
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY ABSTRACT: In direct response to PA-20-071, Advanced-Stage Development and Utilization of Research Infrastructure for Interdis...
Empowering the Management of Pain-Obesity-Weight through Enhanced Reward
PROJECT SUMMARY/ABSTRACT Chronic low back pain (cLBP) is the leading cause of disability worldwide and is one of the top reasons for seeking healthcare.High-impact low back pain is...
Deciphering the effect of human microbiota on Alzheimer's disease using C. elegans models of protein conformational diseases
Alzheimer?s disease (AD) is a fatal neurodegenerative disorder characterized by a progressive loss of memory and cognitive function due to protein misfolding and aggregation, a com...
Cohort Differences in Cognitive Impairment and Alzheimer Disease and Related Dementias: Education Effects and Sex Differences
Project Summary The prevalence rates of cognitive impairment and Alzheimer's disease and related dementias (ADRD) is projected to rise as the population ages, but the trends m...
Transitions in Care for Older Nursing Home Residents with Dementia from Entry to Death: a retrospective cohort study, 2014-2019
Transitions in Care for Older Nursing Home Residents with Alzheimer?s disease and Alzheimer?s disease-related dementias from Entry to Death: a retrospective cohort study, 2014-2019...
Regulation of adipose lineage plasticity in obesity
Title: ?Regulation of adipose lineage plasticity in obesity?Project Summary/Abstract A potential therapeutic target to curb the global obesity and diabetes epidemic is thermogenic...
Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830) a severe developmental and epileptic encephalopathy...
Respiratory dysfunction in Alzheimer's disease and its link to oxidative damage within the brain stem.
PROJECT SUMMARY/ABSTRACT: The majority of Alzheimer's disease (AD) patients exhibit respiratory dysfunction that can lead to poor quality of life and various health complicati...
Chemoprevention of lung cancer with the β-blocker carvedilol
Abstract Lung cancer is the leading cause of cancer-related death for both men and women.Chronic exposure to carcinogens that are present in tobacco smoking or air pollution is a k...
THE ROLE OF HYDROGEN GAS IN HEALTH AND DISEASE
Aberrant redox-sensitive reactions and accumulation of oxidative damage can impair body functions, contribute to the development of various pathologies and accelerate aging.Althoug...
Leukemia stem cell regulation and resistance
PROJECT SUMMARY/ABSTRACT Chronic myelogenous leukemia (CML) results from hematopoietic stem cell (HSC) transformation by the BCR- ABL tyrosine kinase.Tyrosine kinase inhibitors (TK...
Neutral sphingomyelinase-2 as a mediator of Doxorubicin-induced cardiotoxicity
ABSTRACT Doxorubicin (Dox) is a mainstay in the treatment of many cancers yet its utility is limited by cardiovascular toxicity.While multiple mechanisms underlying this cardiotoxi...
Structural basis for ApoE4-induced Alzheimer's disease
Alzheimer's disease (AD) is the 6th leading cause of death in the USA and there are no effective treatments. Moreover, the prevalence of this age-related neurodegenerative dis...
Investigating a dual-pathway framework for praxis
PROJECT SUMMARY Performing skilled actions relies on two fundamental abilities: imitating movements to quickly learn new behaviors, and using tools to more efficiently manipulate o...
New mechanisms of SERCA2a regulation: role of luminal calcium
PROJECT SUMMARY/ABSTRACT SERCA2a Ca pump plays a central role in heart function.The speed at which SERCA2a removes Ca from the cytosol is the main determinant of the rate of cardia...
Role of Negative Elongation Factor Complex in RNA polymerase II pausing and gene transcription in Heart
PROJECT SUMMARY/ABSTRACT Congestive heart failure is one of the leading cause of morbidity and mortality in the USA and the World.However, despite the major advancements in researc...