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99,167 grants found
Showing 95,401 – 95,420 of 99,167 grants
Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapy
Summary: The exquisite specificity, amplitude, and quality of T cells govern tumor initiation, progression, and responses to therapy.Two of the most revolutionary and promising imm...
Elucidating Vascular Neuropilin 1 (NRP1) Functions in Response to Novel Interactions with Insulin Substrates
Project Summary/Abstract Obesity is emerging a major public health challenge in the United States, and around the world. It correlates with several comorbidities including, cardiov...
Regulation of endothelial cell specification
SUMMARY Approaches to vascular regeneration and repair require specification of endothelial cells that are competent to form functioning blood vessels. However, the process by whic...
Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
Project summary Patients with Alzheimer?s disease (AD) are known to have greater balance and gait impairment and double the rate of falls relative to healthy older adults (60-70% v...
Type 1 diabetes genetic risk scores for the diagnosis of diabetes type in children of diverse racial and ethnic background
PROJECT SUMMARY A large and growing number of pediatric diabetes cases cannot be classified at diagnosis with the current criteria, particularly among non-Caucasian children.The lo...
RNA-Binding Proteins in the Regulation of Vascular Inflammation and Immunity
Inflammation is designed to destroy, disable, or contain pathogenic invaders, but must be controlled to avoid destruction of key host systems, like the vasculature.When the interac...
Dissecting the molecular mechanisms of lung injury during mechanical ventilation
Project Summary The acute respiratory distress syndrome (ARDS) is a deadly condition characterized by the rapid onset of hypoxemia and respiratory failure. The mainstay of therapy...
Cellular and Molecular mechanisms of ATRA inhibition of osteoblast-induced MDS development
ABSTRACT Osteoblasts are critical components of the hematopoietic stem cell (HSC) niche that regulate hematopoiesis. More recently, they have emerged as critical regulators of the...
The role of collisions in rescuing stalled ribosomes in bacteria
PROJECT SUMMARY Translating ribosomes often encounter obstacles that stop them in their tracks: the synthesis of roughly 1 out of every 250 proteins in E. coli ends in failure.Ribo...
Targeting altered phosphatase-dependent signaling to overcome the inefficacy of targeted therapy in myeloproliferative neoplasms
Project Summary/Abstract Classical myeloproliferative neoplasms (MPNs) are blood disorders that affect about 300,000 people in the U.S. Blood clotting complications and bone marrow...
Dynamic GABA and Glutamate Neurotransmission in Alzheimer’s Disease and Aging
PROJECT SUMMARY / ABSTRACT Alzheimer?s disease (AD) progression and normal aging are complex and often heterogeneous processes involving functional changes to neuronal and glial el...
Using Technology to Support Care Partners for Persons with Alzheimer's Disease: Tele-STELLA
PROJECT SUMMARY The purpose of this NIH Stage 1B mixed methods study is to test the feasibility, acceptability, fidelity and efficacy of a telehealth-based intervention designed to...
Investigating tandem repeat variation as a cause of Alzheimer's disease from exome sequencing data
Tandem Repeat Expansions (TREs), most commonly of triplet repeats such as poly(CAG), are known to underlie >30 different human neurological diseases. While the majority of TREs...
Investigating astrocytic RIPK3 as a driver of protective neuroinflammation during viral encephalitis
Abstract Astrocytes are versatile glial cells that regulate diverse processes in the central nervous system (CNS). Roles for astrocytes during disease are complex and include both...
Deciphering the effect of human microbiota on Alzheimer's disease using C. elegans models of protein conformational diseases
Alzheimer’s disease (AD) is a fatal neurodegenerative disorder characterized by a progressive loss of memory and cognitive function due to protein misfolding and aggregation, a com...
Cohort Differences in Cognitive Impairment and Alzheimer Disease and Related Dementias: Education Effects and Sex Differences
Project Summary The prevalence rates of cognitive impairment and Alzheimer's disease and related dementias (ADRD) is projected to rise as the population ages, but the trends m...
Sequence Variants Impacting Cardiomyocyte S-phase Activity in Inbred Mice Following Injury
Numerous studies have shown that induction of cardiomyocyte cell cycle activity can have a profound beneficial impact on cardiac structure and function following myocardial infarct...
Circadian clock gene Rev-erb in memory dysfunction in Alzheimer's disease
ABSTRACT/SUMMARY Abnormal circadian rhythms of locomotor activities, body temperature, and hormonal levels not only are strongly associated many neurodegenerative disorders includi...
BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a Trial
PROJECT SUMMARY Acute brain injuries resulting from cerebrovascular injury or trauma, such as intracerebral hemorrhage (ICH) or traumatic brain injury, are major medical problems t...
Utilizing islet autoantibody signatures for precision medicine in type 2 diabetes
For a substantial proportion of patients diagnosed with type 2 diabetes, islet autoimmunity plays an important role in disease onset, risk of complications, and progression to panc...