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99,167 grants found
Showing 95,421 – 95,440 of 99,167 grants
Direct and Mediating Pathways Linking Personal Networks with Cardiovascular Disease
PROJECT SUMMARY/ABSTRACT Personal networks are important for cardiovascular functioning; they not only serve as sources of support and burden, but may also pattern psychosocial str...
Methodology Issues in a Tailored Light Treatment for Persons with Dementia
Project Summary/Abstract This study's principal hypothesis is that delivering a circadian-effective, tailored lighting intervention (TLI) will reveal a strong association betw...
The intersection of stress and environmental chemicals in germ cell reprogramming
PROJECT ABSTRACT The goal of this proposal is to establish how exposures to ubiquitous plastics and prenatal stress interact to confer epigenetic changes to developing germ cells,...
Neural circuit basis for neurovascular coupling
Abstract Neurovascular coupling (NVC) is the temporal relationship between neural activity and cerebral blood flow (CBF).This neural-evoked hemodynamic response is fundamental to l...
The protective role of microglia in preventing hypoxic disruption of blood-brain barrier integrity and VCID
PROJECT SUMMARY/ABSTRACT Dementia is a major health problem in the United States.Vascular contributions to cognitive impairment and dementia (VCID) is the second leading cause of d...
Restorative gene therapy on hippocampal spino-dendritic abnormalities: a focus on Alzheimer’s disease
SUMMARY/ABSTRACT There are currently no effective treatments to prevent, delay, or reverse the memory deficits and neuropathological alterations—specifically dendritic damage and s...
Methodology Issues in a Tailored Light Treatment for Persons with Dementia
Project Summary/Abstract This study's principal hypothesis is that delivering a circadian-effective, tailored lighting intervention (TLI) will reveal a strong association betw...
Computations in human motor learning
Project Summary The long-term goal of our laboratory is to understand the computations underlying human motor learning and thereby provide a framework to examine the neural underpi...
Chemoprevention of lung cancer with the β-blocker carvedilol
Abstract Lung cancer is the leading cause of cancer-related death for both men and women. Chronic exposure to carcinogens that are present in tobacco smoking or air pollution is a...
Clinical Neuroimmunology of Vaccines in Brain Tumors
In brain tumors like glioblastoma (GBM), failures to develop an effective vaccine and achieve immune checkpoint inhibition have been attributed to the extraordinary antigenic intra...
Neutral sphingomyelinase-2 as a mediator of Doxorubicin-induced cardiotoxicity
ABSTRACT Doxorubicin (Dox) is a mainstay in the treatment of many cancers yet its utility is limited by cardiovascular toxicity. While multiple mechanisms underlying this cardiotox...
The role of RGS12 in differential modulation of G protein versus beta-arrestin signaling downstream of the kappa opioid receptor
The kappa opioid receptor (KOR) helps mediate responses to stress, yet is also implicated in developing and/or maintaining health disorders of chronic pain, drug addiction, anxiety...
Exploiting the VISTA Pathway to Prevent Acute GVHD and Control Steroid Refractory Disease
Abstract Despite multi-drug prophylaxis, aGVHD affects 20-70% of allogeneic hematopoietic cell transplant (allo-HCT) patients. V-region Immunoglobulin-containing Suppressor of T ce...
Elucidating hereditary transthyretin-mediated heart failure risk using machine learning, polygenic risk and recall by genotype approaches in African ancestry individuals
PROJECT SUMMARY / ABSTRACT Mutations in the Transthyretin (TTR) gene can lead to deposition of abnormal amyloid fibrils in the myocardium, resulting in hereditary transthyretin amy...
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY ABSTRACT: In direct response to PA-20-071, Advanced-Stage Development and Utilization of Research Infrastructure for Interdis...
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
Abstract/Summary Progress in understanding Alzheimer’s disease and related disorders (ADRD) is close to producing more effective treatments, creating an urgent need for disease-pre...
New mechanisms of SERCA2a regulation: role of luminal calcium
PROJECT SUMMARY/ABSTRACT SERCA2a Ca pump plays a central role in heart function. The speed at which SERCA2a removes Ca from the cytosol is the main determinant of the rate of cardi...
Cannabis use among older adults: Potential risks and benefits to an aging population
Project Summary The population of older adults in the U.S. is increasing dramatically, doubling from 48 million to 88 million by the year 2050. As more Americans live longer, the c...
Elucidating Vascular Neuropilin 1 (NRP1) Functions in Response to Novel Interactions with Insulin Substrates
Project Summary/Abstract Obesity is emerging a major public health challenge in the United States, and around the world. It correlates with several comorbidities including, cardiov...
Cellular and Molecular mechanisms of ATRA inhibition of osteoblast-induced MDS development
ABSTRACT Osteoblasts are critical components of the hematopoietic stem cell (HSC) niche that regulate hematopoiesis. More recently, they have emerged as critical regulators of the...