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99,167 grants found
Showing 95,441 – 95,460 of 99,167 grants
Using Technology to Support Care Partners for Persons with Alzheimer's Disease: Tele-STELLA
PROJECT SUMMARY The purpose of this NIH Stage 1B mixed methods study is to test the feasibility, acceptability, fidelity and efficacy of a telehealth-based intervention designed to...
Chemical Probes as Allosteric Modulators of CK2 Alpha Prime Targeting Huntington's Disease
PROJECT SUMMARY CK2α’, one of two catalytic subunits of human protein kinase CK2 holoenzyme, is inappropriately upregulated in cellular and animal models of Huntington’s disease (H...
DISSECTING THE LINK BETWEEN UREAGENESIS AND HEPATIC GLYCOGEN METABOLISM
PROJECT SUMMARY/ABSTRACT Urea cycle disorders (UCDs) are common inborn errors of hepatic metabolism. With improved therapies such as nitrogen-scavenging agents to prevent elevated...
BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a Trial
PROJECT SUMMARY Acute brain injuries resulting from cerebrovascular injury or trauma, such as intracerebral hemorrhage (ICH) or traumatic brain injury, are major medical problems t...
Characterization of an 18F COX-2 PET ligand for in vivo brain imaging
Alzheimer’s disease (AD) pathogenesis is associated with early neuroinflammation, which is considered to contribute to disease progression and severity.Therefore, understanding and...
Defining cellular states of quiescence in human brain tumors
PROJECT SUMMARY The most aggressive type of brain tumor, grade IV glioma known as glioblastoma (GBM), is one of the few tumor types with both a poor outcome and minimal improvement...
Immigration and Health
Abstract The objective of our proposal is to investigate the causal effect of health insurance coverage on healthcare utilization, health behavior, and health of immigrants living...
Investigating a dual-pathway framework for praxis
PROJECT SUMMARY Performing skilled actions relies on two fundamental abilities: imitating movements to quickly learn new behaviors, and using tools to more efficiently manipulate o...
Thermal proteome profiling for analysis of protein sequence variants in human genetic disease
Project Summary Many global proteomics studies have focused on the measurement of protein abundance and post- translational modification status as measures of cellular function. Th...
Pathogenesis of HIV and HBV Co-Infection in a Humanized Mouse Model
Abstract Approximately 260 million people have chronic hepatitis B virus (HBV) infection, which leads to a spectrum of liver pathologies, including chronic hepatitis, cirrhosis, an...
Validation of an in vitro model of progressive fibrosis that mimics Idiopathic Pulmonary Fibrosis
Abstract We have developed a 3D bioengineered human induced pluripotent stem cell (iPSC) derived model of IPF that displays progressive fibrosis and closely phenocopies several cha...
Utilizing islet autoantibody signatures for precision medicine in type 2 diabetes
For a substantial proportion of patients diagnosed with type 2 diabetes, islet autoimmunity plays an important role in disease onset, risk of complications, and progression to panc...
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
We propose to quantify aging- and AD-associated brain and blood metabolic changes through ex vivo and in vivo multimodality MR measurements in mouse models after an AD-promoting st...
Neurometabolic Outcomes of Different Cardiopulmonary Bypass Strategies
Project Description Patients with congenital cardiac diseases undergoing surgery requiring cardiopulmonary bypass (CPB) are at risk for impaired neurodevelopmental progression due...
Type 1 diabetes genetic risk scores for the diagnosis of diabetes type in children of diverse racial and ethnic background
PROJECT SUMMARY A large and growing number of pediatric diabetes cases cannot be classified at diagnosis with the current criteria, particularly among non-Caucasian children. The l...
Vietnamese Insights into Cognitive Aging Program (VIP)
Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and r...
Staging Alzheimer disease with blood-based biomarkers
The brain changes of Alzheimer disease (AD) start many years before the onset of cognitive symptoms. Most models of AD propose a stepwise progression of brain pathology starting wi...
Chaperome networks in Alzheimer's disease
ABSTRACT The goal of the proposed project is to address how neuronal stress triggered by amyloid-beta and tau oligomeric species induces protein connectivity dysfunctions and alter...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...
Wnt7a-Mediated Competence to Resist Osteoarthritis Progression
Abstract: Wnt7a-mediated competence to resist osteoarthritis progression Osteoarthritis (OA) is a highly prevalent and debilitating disease that currently has no effective therapy....