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99,167 grants found
Showing 95,481 – 95,500 of 99,167 grants
Mechanosensitive cadherin adhesion and its regulation
ABSTRACT Cellular rearrangements during tissue formation, tissue regeneration and cancer metastasis occur via the coupled movement of groups of cells, a phenomenon known as collect...
Regulation of adipose lineage plasticity in obesity
Title: “Regulation of adipose lineage plasticity in obesity” Project Summary/Abstract A potential therapeutic target to curb the global obesity and diabetes epidemic is thermogenic...
A Shared Decision Making Intervention for Diabetes Prevention in Women with a History of Gestational Diabetes Mellitus.
PROJECT SUMMARY/ABSTRACT Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes (T2DM). Evidence from the Diabetes Prevention Pr...
The role of mitochondrial dynamics in diet-influenced regulation of food intake and adiposity
We have identified a role for mitochondrial dynamics (fission and fusion) in central regulation of feeding, energy- and glucose metabolism.We showed that mitochondrial fission is i...
Cryo-ET Structural Biology of Herpesvirus Infection and Morphogenesis In Situ.
Herpesviruses are pathogens of medical and economic significance that cause a range of diseases in humans and animals.Varicella-zoster virus (VZV) is an important human alpha herpe...
Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone Maturation
The current proposal describes experimental approaches to determine how neurons regulate structural and functional maturation of active zones (AZs), a key signaling hub where synap...
Dissecting the molecular mechanisms of lung injury during mechanical ventilation
Project Summary The acute respiratory distress syndrome (ARDS) is a deadly condition characterized by the rapid onset of hypoxemia and respiratory failure. The mainstay of therapy...
Mechanosensitive cadherin adhesion and its regulation
ABSTRACT Cellular rearrangements during tissue formation, tissue regeneration and cancer metastasis occur via the coupled movement of groups of cells, a phenomenon known as collect...
Type 1 diabetes genetic risk scores for the diagnosis of diabetes type in children of diverse racial and ethnic background
PROJECT SUMMARY A large and growing number of pediatric diabetes cases cannot be classified at diagnosis with the current criteria, particularly among non-Caucasian children. The l...
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
Abstract/Summary Progress in understanding Alzheimer’s disease and related disorders (ADRD) is close to producing more effective treatments, creating an urgent need for disease-pre...
Chaperome networks in Alzheimer's disease
ABSTRACT The goal of the proposed project is to address how neuronal stress triggered by amyloid-beta and tau oligomeric species induces protein connectivity dysfunctions and alter...
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
We propose to quantify aging- and AD-associated brain and blood metabolic changes through ex vivo and in vivo multimodality MR measurements in mouse models after an AD-promoting st...
Thermal proteome profiling for analysis of protein sequence variants in human genetic disease
Project Summary Many global proteomics studies have focused on the measurement of protein abundance and post- translational modification status as measures of cellular function. Th...
Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone Maturation
The current proposal describes experimental approaches to determine how neurons regulate structural and functional maturation of active zones (AZs), a key signaling hub where synap...
Biopsy Tract Sealing Device with Magnetic Resonance and X-Ray Image Contrast
PROJECT SUMMARY When cancer is suspected in a patient, the tissue in question must be removed and analyzed. This procedure is called a biopsy and is a crucial step in early detecti...
Utilizing islet autoantibody signatures for precision medicine in type 2 diabetes
For a substantial proportion of patients diagnosed with type 2 diabetes, islet autoimmunity plays an important role in disease onset, risk of complications, and progression to panc...
Computations in Human Motor Learning
Project Summary The long-term goal of our laboratory is to understand the computations underlying human motor learning and thereby provide a framework to examine the neural underpi...
Vietnamese Insights into Cognitive Aging Program (VIP)
Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and r...
Pathways to improved adolescent mental health via an economic and gender equality intervention with conflict affected families
Project Summary/Abstract In the Democratic Republic of Congo, families have experienced more than two decades of violence, displacement and political instability resulting in extre...
Gut barrier function in Alzheimer’s disease
The age-related processes that contribute to Alzheimer's disease (AD) development, particularly in the prodromal period, are incompletely understood. Age-related reduction in...