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99,167 grants found
Showing 95,501 – 95,520 of 99,167 grants
Leukemia stem cell regulation and resistance
PROJECT SUMMARY/ABSTRACT Chronic myelogenous leukemia (CML) results from hematopoietic stem cell (HSC) transformation by the BCR- ABL tyrosine kinase. Tyrosine kinase inhibitors (T...
Neutral sphingomyelinase-2 as a mediator of Doxorubicin-induced cardiotoxicity
ABSTRACT Doxorubicin (Dox) is a mainstay in the treatment of many cancers yet its utility is limited by cardiovascular toxicity. While multiple mechanisms underlying this cardiotox...
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
Hypoplastic left heart syndrome (HLHS) is a severe type of congenital heart defects, which is characterized by the underdevelopment of left side of the heart. The clinical presenta...
Neurometabolic Outcomes of Different Cardiopulmonary Bypass Strategies
Project Description Patients with congenital cardiac diseases undergoing surgery requiring cardiopulmonary bypass (CPB) are at risk for impaired neurodevelopmental progression due...
Metal Exposure and Subclinical Lung Disease in Adult E-cigarette Users
E-cigarette (e-cig) use is common, particularly among adolescents and young adults, and has been associated with E-cigarette and Vaping Associated Lung Injury (EVALI). To address m...
Alzheimer's Disease Pathology in a Primate Model
Project Summary Alzheimer's disease (AD) is a major health concern defined by pathologic changes in the brain that coincide with altered behavior and cognitive function. Anima...
Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapy
Summary: The exquisite specificity, amplitude, and quality of T cells govern tumor initiation, progression, and responses to therapy.Two of the most revolutionary and promising imm...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...
Wnt7a-Mediated Competence to Resist Osteoarthritis Progression
Abstract: Wnt7a-mediated competence to resist osteoarthritis progression Osteoarthritis (OA) is a highly prevalent and debilitating disease that currently has no effective therapy....
Cellular and molecular analysis of startle modulation
Abstract A remarkable feature of the nervous system is its ability to adjust stereotyped behavioral responses in a context dependent manner. In vertebrates, sudden and intense acou...
Staging Alzheimer disease with blood-based biomarkers
The brain changes of Alzheimer disease (AD) start many years before the onset of cognitive symptoms. Most models of AD propose a stepwise progression of brain pathology starting wi...
Elucidating hereditary transthyretin-mediated heart failure risk using machine learning, polygenic risk and recall by genotype approaches in African ancestry individuals
PROJECT SUMMARY / ABSTRACT Mutations in the Transthyretin (TTR) gene can lead to deposition of abnormal amyloid fibrils in the myocardium, resulting in hereditary transthyretin amy...
Cannabis use among older adults: Potential risks and benefits to an aging population
Project Summary The population of older adults in the U.S. is increasing dramatically, doubling from 48 million to 88 million by the year 2050. As more Americans live longer, the c...
Evaluating Advanced Diffusion of the Human Spinal Cord: Application to MS
Project Summary We propose to optimize and validate two novel diffusion MRI models/methods that have direct clinical relevance for cervical spinal cord evaluation in health and mul...
Utilizing islet autoantibody signatures for precision medicine in type 2 diabetes
For a substantial proportion of patients diagnosed with type 2 diabetes, islet autoimmunity plays an important role in disease onset, risk of complications, and progression to panc...
Dissecting the role of sialic acid and sialidase in the pathophysiology of Porphyromonas gingivalis
The overarching goal of this application is to investigate the role of sialidase and sialic acid in the keystone pathogen Porphyromonas gingivalis (Pg) and their contributions to t...
Targeting the orexin pathway to treat sleep disorders and improve glymphatic clearance in Alzheimer’s disease
PROJECT SUMMARY/ABSTRACT FOR FUNDED GRANT Note, this is a redundant copy required by our submission system, the abstract is also included within the 5 page Research strategy as req...
BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a Trial
PROJECT SUMMARY Acute brain injuries resulting from cerebrovascular injury or trauma, such as intracerebral hemorrhage (ICH) or traumatic brain injury, are major medical problems t...
Biopsy Tract Sealing Device with Magnetic Resonance and X-Ray Image Contrast
PROJECT SUMMARY When cancer is suspected in a patient, the tissue in question must be removed and analyzed. This procedure is called a biopsy and is a crucial step in early detecti...
Gut barrier function in Alzheimer's Disease
SUMMARY______________________________________________________________________________ The age-related processes that contribute to Alzheimer's disease (AD) development, partic...