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99,167 grants found
Showing 95,521 – 95,540 of 99,167 grants
Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone Maturation
The current proposal describes experimental approaches to determine how neurons regulate structural and functional maturation of active zones (AZs), a key signaling hub where synap...
Locomotor Recovery and Compensation Post-stroke
Project Summary The objective of this project is to identify the trajectory of neurological and locomotor recovery in patients early post-stroke and the biomechanical strategies us...
Targeting altered phosphatase-dependent signaling to overcome the inefficacy of targeted therapy in myeloproliferative neoplasms
Project Summary/Abstract Classical myeloproliferative neoplasms (MPNs) are blood disorders that affect about 300,000 people in the U.S. Blood clotting complications and bone marrow...
PKD proteins in endothelial cells
Project Summary Endothelial cells line the wall of all blood vessels and regulate a wide variety of functions, including contractility which controls systemic blood pressure. Dysfu...
Novel regulators, components and function of endothelial diaphragms
Endothelial diaphragms are protein barriers associated with vascular endothelial subcellular structures, such as fenestrae, transendothelial channels (TEC), caveolae and vesiculo-v...
Computations in Human Motor Learning
Project Summary The long-term goal of our laboratory is to understand the computations underlying human motor learning and thereby provide a framework to examine the neural underpi...
DISSECTING THE LINK BETWEEN UREAGENESIS AND HEPATIC GLYCOGEN METABOLISM
PROJECT SUMMARY/ABSTRACT Urea cycle disorders (UCDs) are common inborn errors of hepatic metabolism. With improved therapies such as nitrogen-scavenging agents to prevent elevated...
Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830) a severe developmental and epileptic encephalopathy...
RNA-Binding Proteins in the Regulation of Vascular Inflammation and Immunity
Inflammation is designed to destroy, disable, or contain pathogenic invaders, but must be controlled to avoid destruction of key host systems, like the vasculature. When the intera...
Cannabis use among older adults: Potential risks and benefits to an aging population
Project Summary The population of older adults in the U.S. is increasing dramatically, doubling from 48 million to 88 million by the year 2050.As more Americans live longer, the ch...
Defining the functional organization of cerebellar output circuits that control feeding behavior
Project Summary In addition to motor and classical conditioning functions, the cerebellum contributes to motivation and reward processes that underlie complex behaviors.To influenc...
Opto-Electrical Cochlear Implants
Project Summary / Abstract Our goal is to develop an optical cochlear implant (oCI) that uses photons to stimulate surviving auditory neurons in severely-to-profoundly deaf.The ben...
Neurometabolic Outcomes of Different Cardiopulmonary Bypass Strategies
Project Description Patients with congenital cardiac diseases undergoing surgery requiring cardiopulmonary bypass (CPB) are at risk for impaired neurodevelopmental progression due...
Alzheimer's Disease Pathology in a Primate Model
Project Summary Alzheimer's disease (AD) is a major health concern defined by pathologic changes in the brain that coincide with altered behavior and cognitive function.Animal...
Vietnamese Insights into Cognitive Aging Program (VIP)
Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and r...
Flortaucipir PET and histopathology in frontotemporal lobar degeneration and Alzheimer’s disease
PROJECT SUMMARY Molecular tau PET imaging has been available for the past four years and is able to detect paired helical filament (PHF) tau in Alzheimer?s disease. The most extens...
Staging Alzheimer disease with blood-based biomarkers
The brain changes of Alzheimer disease (AD) start many years before the onset of cognitive symptoms.Most models of AD propose a stepwise progression of brain pathology starting wit...
Gut barrier function in Alzheimer’s disease
The age-related processes that contribute to Alzheimer's disease (AD) development, particularly in the prodromal period, are incompletely understood.Age-related reduction in g...
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
Abstract/Summary Progress in understanding Alzheimer?s disease and related disorders (ADRD) is close to producing more effective treatments, creating an urgent need for disease-pre...
Chemical Probes as Allosteric Modulators of CK2 Alpha Prime Targeting Huntington's Disease
PROJECT SUMMARY CK2??, one of two catalytic subunits of human protein kinase CK2 holoenzyme, is inappropriately upregulated in cellular and animal models of Huntington?s disease (H...