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99,167 grants found
Showing 95,541 – 95,560 of 99,167 grants
Mechanosensitive cadherin adhesion and its regulation
ABSTRACT Cellular rearrangements during tissue formation, tissue regeneration and cancer metastasis occur via the coupled movement of groups of cells, a phenomenon known as collect...
Wnt7a-Mediated Competence to Resist Osteoarthritis Progression
Abstract: Wnt7a-mediated competence to resist osteoarthritis progression Osteoarthritis (OA) is a highly prevalent and debilitating disease that currently has no effective therapy....
Cortical-hippocampal brain dynamics during sleep following spatial learning in rodents modeling Tau and AB aggregation feature of Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease is devastating for individuals and society. Impaired learning and memory, particularly in the context of spatial navigation, is one of...
Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830) a severe developmental and epileptic encephalopathy...
PKD proteins in endothelial cells
Project Summary Endothelial cells line the wall of all blood vessels and regulate a wide variety of functions, including contractility which controls systemic blood pressure. Dysfu...
Sequence Variants Impacting Cardiomyocyte S-phase Activity in Inbred Mice Following Injury
Numerous studies have shown that induction of cardiomyocyte cell cycle activity can have a profound beneficial impact on cardiac structure and function following myocardial infarct...
Novel regulators, components and function of endothelial diaphragms
Endothelial diaphragms are protein barriers associated with vascular endothelial subcellular structures, such as fenestrae, transendothelial channels (TEC), caveolae and vesiculo-v...
Clonal hematopoiesis, inflammasomes and atherosclerosis
Project Summary/Abstract The recent CANTOS trial showed that administration of an antibody targeting IL-1b reduced coronary events, supporting the concept of anti-inflammatory ther...
Targeting altered phosphatase-dependent signaling to overcome the inefficacy of targeted therapy in myeloproliferative neoplasms
Project Summary/Abstract Classical myeloproliferative neoplasms (MPNs) are blood disorders that affect about 300,000 people in the U.S. Blood clotting complications and bone marrow...
Restorative gene therapy on hippocampal spino-dendritic abnormalities: a focus on Alzheimer’s disease
SUMMARY/ABSTRACT There are currently no effective treatments to prevent, delay, or reverse the memory deficits and neuropathological alterations?specifically dendritic damage and s...
Chaperome networks in Alzheimer's disease
ABSTRACT The goal of the proposed project is to address how neuronal stress triggered by amyloid-beta and tau oligomeric species induces protein connectivity dysfunctions and alter...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors.Investigations of the therapeutic relevance of STING agonist...
Sulfatide deficiency: A novel mechanism leading to reactive astrogliosis in aging and Alzheimer’s disease
Project Summary Aging is the greatest known risk factor for Alzheimer's disease (AD), the most common cause of dementia in older individuals.However, effective AD therapies re...
A Shared Decision Making Intervention for Diabetes Prevention in Women with a History of Gestational Diabetes Mellitus.
PROJECT SUMMARY/ABSTRACT Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes (T2DM).Evidence from the Diabetes Prevention Pro...
A Longitudinal Mixed-Methods Investigation of Masculinity, Stigma, and Disclosure on Men's ART Initiation in South Africa
Project Summary South Africa is home to over 7.9 million people living with HIV, the largest of any country globally.One significant barrier to ending the HIV epidemic is engaging...
Immigration and Health
Abstract The objective of our proposal is to investigate the causal effect of health insurance coverage on healthcare utilization, health behavior, and health of immigrants living...
The role of mitochondrial dynamics in diet-influenced regulation of food intake and adiposity
We have identified a role for mitochondrial dynamics (fission and fusion) in central regulation of feeding, energy- and glucose metabolism.We showed that mitochondrial fission is i...
Investigating astrocytic RIPK3 as a driver of protective neuroinflammation during viral encephalitis
Abstract Astrocytes are versatile glial cells that regulate diverse processes in the central nervous system (CNS). Roles for astrocytes during disease are complex and include both...
Thermal proteome profiling for analysis of protein sequence variants in human genetic disease
Project Summary Many global proteomics studies have focused on the measurement of protein abundance and post- translational modification status as measures of cellular function.The...
Cryo-ET Structural Biology of Herpesvirus Infection and Morphogenesis In Situ.
Herpesviruses are pathogens of medical and economic significance that cause a range of diseases in humans and animals.Varicella-zoster virus (VZV) is an important human alpha herpe...