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99,167 grants found
Showing 95,561 – 95,580 of 99,167 grants
Genetic code expansion to enable the development of short, diverse peptide libraries
Project Summary Many intracellular cancer targets involve protein-protein interactions that are ?undruggable? because the binding surfaces are too large and featureless to be block...
Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone Maturation
The current proposal describes experimental approaches to determine how neurons regulate structural and functional maturation of active zones (AZs), a key signaling hub where synap...
Computations in human motor learning
Project Summary The long-term goal of our laboratory is to understand the computations underlying human motor learning and thereby provide a framework to examine the neural underpi...
Locomotor Recovery and Compensation Post-stroke
Project Summary The objective of this project is to identify the trajectory of neurological and locomotor recovery in patients early post-stroke and the biomechanical strategies us...
Gardnerella vaginalis small colony variants
PROJECT SUMMARY Bacterial vaginosis (BV) is the most common gynecological disorder in women of childbearing age and is associated with adverse pregnancy outcomes and enhanced trans...
Evaluating Advanced Diffusion of the Human Spinal Cord: Application to MS
Project Summary We propose to optimize and validate two novel diffusion MRI models/methods that have direct clinical relevance for cervical spinal cord evaluation in health and mul...
RNA-Binding Proteins in the Regulation of Vascular Inflammation and Immunity
Inflammation is designed to destroy, disable, or contain pathogenic invaders, but must be controlled to avoid destruction of key host systems, like the vasculature. When the intera...
The role of RGS12 in differential modulation of G protein versus beta-arrestin signaling downstream of the kappa opioid receptor
The kappa opioid receptor (KOR) helps mediate responses to stress, yet is also implicated in developing and/or maintaining health disorders of chronic pain, drug addiction, anxiety...
Validation of an in vitro model of progressive fibrosis that mimics Idiopathic Pulmonary Fibrosis
Abstract We have developed a 3D bioengineered human induced pluripotent stem cell (iPSC) derived model of IPF that displays progressive fibrosis and closely phenocopies several cha...
Cellular and molecular analysis of startle modulation
Abstract A remarkable feature of the nervous system is its ability to adjust stereotyped behavioral responses in a context dependent manner. In vertebrates, sudden and intense acou...
Small RNA Regulation in Bacteria
PROJECT SUMMARY Bacteria must sense and respond to rapidly changing and often stressful environments.Their ability to enact rapid changes in gene expression that alter cell structu...
Investigating tandem repeat variation as a cause of Alzheimer's disease from exome sequencing data
Tandem Repeat Expansions (TREs), most commonly of triplet repeats such as poly(CAG), are known to underlie >30 different human neurological diseases.While the majority of TREs i...
Exploiting the VISTA Pathway to Prevent Acute GVHD and Control Steroid Refractory Disease
Abstract Despite multi-drug prophylaxis, aGVHD affects 20-70% of allogeneic hematopoietic cell transplant (allo-HCT) patients.V-region Immunoglobulin-containing Suppressor of T cel...
A Novel Neural Mechanism that Mediates the Therapeutic Effects of Metformin
Metformin is the most prescribed first-line anti-diabetic drug.It has been widely accepted that metformin lowers blood glucose primarily by reducing glucose output in the liver, an...
Biopsy Tract Sealing Device with Magnetic Resonance and X-Ray Image Contrast
PROJECT SUMMARY When cancer is suspected in a patient, the tissue in question must be removed and analyzed. This procedure is called a biopsy and is a crucial step in early detecti...
DISSECTING THE LINK BETWEEN UREAGENESIS AND HEPATIC GLYCOGEN METABOLISM
PROJECT SUMMARY/ABSTRACT Urea cycle disorders (UCDs) are common inborn errors of hepatic metabolism.With improved therapies such as nitrogen-scavenging agents to prevent elevated a...
Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart disease
PROJECT SUMMARY/ABSTRACT Aging is accompanied by increasing vulnerability to cardiovascular disease (CVD) and Alzheimer?s disease (AD).The ongoing rise in both AD and CVD has been...
Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
Project summary Patients with Alzheimer’s disease (AD) are known to have greater balance and gait impairment and double the rate of falls relative to healthy older adults (60-70% v...
Biopsy Tract Sealing Device with Magnetic Resonance and X-Ray Image Contrast
PROJECT SUMMARY When cancer is suspected in a patient, the tissue in question must be removed and analyzed. This procedure is called a biopsy and is a crucial step in early detecti...
Regulation of endothelial cell specification
SUMMARY Approaches to vascular regeneration and repair require specification of endothelial cells that are competent to form functioning blood vessels. However, the process by whic...