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99,167 grants found
Showing 95,581 – 95,600 of 99,167 grants
Exploiting the VISTA Pathway to Prevent Acute GVHD and Control Steroid Refractory Disease
Abstract Despite multi-drug prophylaxis, aGVHD affects 20-70% of allogeneic hematopoietic cell transplant (allo-HCT) patients. V-region Immunoglobulin-containing Suppressor of T ce...
Evaluating Advanced Diffusion of the Human Spinal Cord: Application to MS
Project Summary We propose to optimize and validate two novel diffusion MRI models/methods that have direct clinical relevance for cervical spinal cord evaluation in health and mul...
Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830) a severe developmental and epileptic encephalopathy...
Defining the functional organization of cerebellar output circuits that control feeding behavior
Project Summary In addition to motor and classical conditioning functions, the cerebellum contributes to motivation and reward processes that underlie complex behaviors. To influen...
Flortaucipir PET and histopathology in frontotemporal lobar degeneration and Alzheimer’s disease
PROJECT SUMMARY Molecular tau PET imaging has been available for the past four years and is able to detect paired helical filament (PHF) tau in Alzheimer’s disease. The most extens...
Opto-Electrical Cochlear Implants
Project Summary / Abstract Our goal is to develop an optical cochlear implant (oCI) that uses photons to stimulate surviving auditory neurons in severely-to-profoundly deaf. The be...
Investigating a dual-pathway framework for praxis
PROJECT SUMMARY Performing skilled actions relies on two fundamental abilities: imitating movements to quickly learn new behaviors, and using tools to more efficiently manipulate o...
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY ABSTRACT: In direct response to PA-20-071, Advanced-Stage Development and Utilization of Research Infrastructure for Interdis...
Investigating astrocytic RIPK3 as a driver of protective neuroinflammation during viral encephalitis
Abstract Astrocytes are versatile glial cells that regulate diverse processes in the central nervous system (CNS). Roles for astrocytes during disease are complex and include both...
Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart disease
PROJECT SUMMARY/ABSTRACT Aging is accompanied by increasing vulnerability to cardiovascular disease (CVD) and Alzheimer’s disease (AD). The ongoing rise in both AD and CVD has been...
Dynamic GABA and Glutamate Neurotransmission in Alzheimer’s Disease and Aging
PROJECT SUMMARY / ABSTRACT Alzheimer’s disease (AD) progression and normal aging are complex and often heterogeneous processes involving functional changes to neuronal and glial el...
Circadian clock gene Rev-erb in memory dysfunction in Alzheimer's disease
ABSTRACT/SUMMARY Abnormal circadian rhythms of locomotor activities, body temperature, and hormonal levels not only are strongly associated many neurodegenerative disorders includi...
Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
Project summary Patients with Alzheimer’s disease (AD) are known to have greater balance and gait impairment and double the rate of falls relative to healthy older adults (60-70% v...
Sulfatide deficiency: A novel mechanism leading to reactive astrogliosis in aging and Alzheimer’s disease
Project Summary Aging is the greatest known risk factor for Alzheimer's disease (AD), the most common cause of dementia in older individuals. However, effective AD therapies r...
Sequence Variants Impacting Cardiomyocyte S-phase Activity in Inbred Mice Following Injury
Numerous studies have shown that induction of cardiomyocyte cell cycle activity can have a profound beneficial impact on cardiac structure and function following myocardial infarct...
Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapy
Summary: The exquisite specificity, amplitude, and quality of T cells govern tumor initiation, progression, and responses to therapy.Two of the most revolutionary and promising imm...
Alzheimer's Disease Pathology in a Primate Model
Project Summary Alzheimer's disease (AD) is a major health concern defined by pathologic changes in the brain that coincide with altered behavior and cognitive function. Anima...
Leukemia stem cell regulation and resistance
PROJECT SUMMARY/ABSTRACT Chronic myelogenous leukemia (CML) results from hematopoietic stem cell (HSC) transformation by the BCR- ABL tyrosine kinase. Tyrosine kinase inhibitors (T...
Cortical-hippocampal brain dynamics during sleep following spatial learning in rodents modeling Tau and AB aggregation feature of Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease is devastating for individuals and society. Impaired learning and memory, particularly in the context of spatial navigation, is one of...
Vietnamese Insights into Cognitive Aging Program (VIP)
Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and r...