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99,167 grants found
Showing 95,601 – 95,620 of 99,167 grants
Mechanosensitive cadherin adhesion and its regulation
ABSTRACT Cellular rearrangements during tissue formation, tissue regeneration and cancer metastasis occur via the coupled movement of groups of cells, a phenomenon known as collect...
Small RNA Regulation in Bacteria
PROJECT SUMMARY Bacteria must sense and respond to rapidly changing and often stressful environments. Their ability to enact rapid changes in gene expression that alter cell struct...
Cellular and molecular analysis of startle modulation
Abstract A remarkable feature of the nervous system is its ability to adjust stereotyped behavioral responses in a context dependent manner. In vertebrates, sudden and intense acou...
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
Abstract/Summary Progress in understanding Alzheimer’s disease and related disorders (ADRD) is close to producing more effective treatments, creating an urgent need for disease-pre...
Dissecting the molecular mechanisms of lung injury during mechanical ventilation
Project Summary The acute respiratory distress syndrome (ARDS) is a deadly condition characterized by the rapid onset of hypoxemia and respiratory failure. The mainstay of therapy...
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
We propose to quantify aging- and AD-associated brain and blood metabolic changes through ex vivo and in vivo multimodality MR measurements in mouse models after an AD-promoting st...
Defining the functional organization of cerebellar output circuits that control feeding behavior
Project Summary In addition to motor and classical conditioning functions, the cerebellum contributes to motivation and reward processes that underlie complex behaviors. To influen...
Type 1 diabetes genetic risk scores for the diagnosis of diabetes type in children of diverse racial and ethnic background
PROJECT SUMMARY A large and growing number of pediatric diabetes cases cannot be classified at diagnosis with the current criteria, particularly among non-Caucasian children. The l...
Pathways to improved adolescent mental health via an economic and gender equality intervention with conflict affected families
Project Summary/Abstract In the Democratic Republic of Congo, families have experienced more than two decades of violence, displacement and political instability resulting in extre...
Metal Exposure and Subclinical Lung Disease in Adult E-cigarette Users
E-cigarette (e-cig) use is common, particularly among adolescents and young adults, and has been associated with E-cigarette and Vaping Associated Lung Injury (EVALI). To address m...
Modeling a Neural Circuit for Flexible Control of Innate Behaviors
The adaptive control of social behaviors, such as aggression and reproduction, is a critical function of the nervous system. In the past decade, new methods for genetically targete...
Investigating a dual-pathway framework for praxis
PROJECT SUMMARY Performing skilled actions relies on two fundamental abilities: imitating movements to quickly learn new behaviors, and using tools to more efficiently manipulate o...
Neurometabolic Outcomes of Different Cardiopulmonary Bypass Strategies
Project Description Patients with congenital cardiac diseases undergoing surgery requiring cardiopulmonary bypass (CPB) are at risk for impaired neurodevelopmental progression due...
Clonal hematopoiesis, inflammasomes and atherosclerosis
Project Summary/Abstract The recent CANTOS trial showed that administration of an antibody targeting IL-1b reduced coronary events, supporting the concept of anti-inflammatory ther...
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY ABSTRACT: In direct response to PA-20-071, Advanced-Stage Development and Utilization of Research Infrastructure for Interdis...
An integrated human stem cell model for elucidating NOTCH signaling in myocardial-endocardial interactions in cardiac development and disease
Hypoplastic left heart syndrome (HLHS) is a severe type of congenital heart defects, which is characterized by the underdevelopment of left side of the heart. The clinical presenta...
Using Technology to Support Care Partners for Persons with Alzheimer's Disease: Tele-STELLA
PROJECT SUMMARY The purpose of this NIH Stage 1B mixed methods study is to test the feasibility, acceptability, fidelity and efficacy of a telehealth-based intervention designed to...
Targeting altered phosphatase-dependent signaling to overcome the inefficacy of targeted therapy in myeloproliferative neoplasms
Project Summary/Abstract Classical myeloproliferative neoplasms (MPNs) are blood disorders that affect about 300,000 people in the U.S. Blood clotting complications and bone marrow...
Regulation of endothelial cell specification
SUMMARY Approaches to vascular regeneration and repair require specification of endothelial cells that are competent to form functioning blood vessels. However, the process by whic...
Novel regulators, components and function of endothelial diaphragms
Endothelial diaphragms are protein barriers associated with vascular endothelial subcellular structures, such as fenestrae, transendothelial channels (TEC), caveolae and vesiculo-v...