Browse All Grants
99,167 grants found
Showing 95,621 – 95,640 of 99,167 grants
Methodology Issues in a Tailored Light Treatment for Persons with Dementia
Project Summary/Abstract This study's principal hypothesis is that delivering a circadian-effective, tailored lighting intervention (TLI) will reveal a strong association betw...
PKD proteins in endothelial cells
Project Summary Endothelial cells line the wall of all blood vessels and regulate a wide variety of functions, including contractility which controls systemic blood pressure. Dysfu...
RNA-Binding Proteins in the Regulation of Vascular Inflammation and Immunity
Inflammation is designed to destroy, disable, or contain pathogenic invaders, but must be controlled to avoid destruction of key host systems, like the vasculature. When the intera...
Neutral sphingomyelinase-2 as a mediator of Doxorubicin-induced cardiotoxicity
ABSTRACT Doxorubicin (Dox) is a mainstay in the treatment of many cancers yet its utility is limited by cardiovascular toxicity. While multiple mechanisms underlying this cardiotox...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...
Neural circuit basis for neurovascular coupling
Abstract Neurovascular coupling (NVC) is the temporal relationship between neural activity and cerebral blood flow (CBF). This neural-evoked hemodynamic response is fundamental to...
Investigating astrocytic RIPK3 as a driver of protective neuroinflammation during viral encephalitis
Abstract Astrocytes are versatile glial cells that regulate diverse processes in the central nervous system (CNS). Roles for astrocytes during disease are complex and include both...
Elucidating Vascular Neuropilin 1 (NRP1) Functions in Response to Novel Interactions with Insulin Substrates
Project Summary/Abstract Obesity is emerging a major public health challenge in the United States, and around the world. It correlates with several comorbidities including, cardiov...
Juan Angel_Diversity Supplement: R01 NS120895
Abstract Astrocytes are versatile glial cells that regulate diverse processes in the central nervous system (CNS). Roles for astrocytes during disease are complex and include both...
Dissecting the role of sialic acid and sialidase in the pathophysiology of Porphyromonas gingivalis
The overarching goal of this application is to investigate the role of sialidase and sialic acid in the keystone pathogen Porphyromonas gingivalis (Pg) and their contributions to t...
m6A Epitranscriptomics in Toxicant Associated Steatohepatitis
Project Summary/Abstract Exposure to persistent environmental contaminants including polychlorinated biphenyls (PCBs) contributes to metabolic diseases including toxicant-associate...
Research Supplement to Promote Diversity for R01 Pediatric Health in Extreme Weather - Health Effects and Ambient Temperature (PHEW - HEAT)
Project Summary/ Abstract While a growing number of studies corroborate that heat is associated with pediatric health impacts, this area of heat and child health remains critically...
Pathogenesis of HIV and HBV Co-Infection in a Humanized Mouse Model
Abstract Approximately 260 million people have chronic hepatitis B virus (HBV) infection, which leads to a spectrum of liver pathologies, including chronic hepatitis, cirrhosis, an...
Modeling a Neural Circuit for Flexible Control of Innate Behaviors
The adaptive control of social behaviors, such as aggression and reproduction, is a critical function of the nervous system.In the past decade, new methods for genetically targeted...
A Dyadic Approach to Perinatal Depression Treatment in Primary Care
Project Summary Ten to 20% of women have depression in the perinatal period (pregnancy through one year postpartum), especially low income racial /ethnic minority women, yet many d...
Novel high-throughput in vivo approach to define pathobionts driving colitis
ABSTRACT Patients with Inflammatory Bowel Diseases (IBD) experience chronic intestinal inflammation as a consequence of inappropriate immune responses to the microbiota.Patients wi...
Use and Effectiveness of Infection Prophylaxis Strategies in a National Cohort of Patients with ANCA Vasculitis
PROJECT SUMMARY/ABSTRACT Reducing infection risk is a priority in patients with antineutrophil cytoplasmic autoantibody (ANCA) ? associated vasculitis (AAV), a group of rare, life-...
Understanding and Respecting End-of-Life Treatment Preferences Among Older Adults with Alzheimer's Disease and Related Dementias
Understanding and Respecting End-of-Life Treatment Preferences Among Older Adults with Alzheimer's Disease and Related Dementias Project Summary/Abstract Cognitive impairment...
Novel high-throughput in vivo approach to define pathobionts driving colitis
ABSTRACT Patients with Inflammatory Bowel Diseases (IBD) experience chronic intestinal inflammation as a consequence of inappropriate immune responses to the microbiota. Patients w...
Use and Effectiveness of Infection Prophylaxis Strategies in a National Cohort of Patients with ANCA Vasculitis
PROJECT SUMMARY/ABSTRACT Reducing infection risk is a priority in patients with antineutrophil cytoplasmic autoantibody (ANCA) – associated vasculitis (AAV), a group of rare, life-...