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Understanding and Respecting End-of-Life Treatment Preferences Among Older Adults with Alzheimer's Disease and Related Dementias
Understanding and Respecting End-of-Life Treatment Preferences Among Older Adults with Alzheimer's Disease and Related Dementias Project Summary/Abstract Cognitive impairment...
Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk
PROJECT SUMMARY/ABSTRACT Antipsychotic-induced weight gain (AIWG) is of significant public health importance in mentally ill populations, potentially addressable with personalized,...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis.CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Computational Methods for Assembling Multiple RNA-seq Samples
PROJECT SUMMARY / ABSTRACT RNA-seq has become standard routine in many biological and biomedical experiments to study gene activities.A very first step of RNA-seq analysis is usual...
Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) accounts for nearly 31,000 deaths annually in the United States alone.Factors that epigenetically silence an HCC tumor suppressor gen...
Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression.In fact, our analysis of the cancer genome atlas (TC...
Transitional dendritic cells: identifying the origin and role of a novel innate immune population during viral infection
ABSTRACT Plasmacytoid dendritic cells (pDCs) are a unique subset of innate immune cells capable of multiple functions essential for antiviral responses, including type I interferon...
Investigating the sex-specific roles of PKLR and CHCHD6 in insulin resistance and NAFLD
PROJECT SUMMARY/ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is increasingly being recognized as the hepatic manifestation of metabolic syndrome that can lead to cardiovascul...
Computational Methods for Assembling Multiple RNA-seq Samples
PROJECT SUMMARY / ABSTRACT RNA-seq has become standard routine in many biological and biomedical experiments to study gene activities. A very first step of RNA-seq analysis is usua...
Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression. In fact, our analysis of the cancer genome atlas (T...
Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk
PROJECT SUMMARY/ABSTRACT Antipsychotic-induced weight gain (AIWG) is of significant public health importance in mentally ill populations, potentially addressable with personalized,...
Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) accounts for nearly 31,000 deaths annually in the United States alone. Factors that epigenetically silence an HCC tumor suppressor ge...
Transitional dendritic cells: identifying the origin and role of a novel innate immune population during viral infection
ABSTRACT Plasmacytoid dendritic cells (pDCs) are a unique subset of innate immune cells capable of multiple functions essential for antiviral responses, including type I interferon...
Investigating the sex-specific roles of PKLR and CHCHD6 in insulin resistance and NAFLD
PROJECT SUMMARY/ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is increasingly being recognized as the hepatic manifestation of metabolic syndrome that can lead to cardiovascul...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis. CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk
PROJECT SUMMARY/ABSTRACT Antipsychotic-induced weight gain (AIWG) is of significant public health importance in mentally ill populations, potentially addressable with personalized,...
Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) accounts for nearly 31,000 deaths annually in the United States alone. Factors that epigenetically silence an HCC tumor suppressor ge...
Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression. In fact, our analysis of the cancer genome atlas (T...
Computational Methods for Assembling Multiple RNA-seq Samples
PROJECT SUMMARY / ABSTRACT RNA-seq has become standard routine in many biological and biomedical experiments to study gene activities. A very first step of RNA-seq analysis is usua...
Investigating the sex-specific roles of PKLR and CHCHD6 in insulin resistance and NAFLD
PROJECT SUMMARY/ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is increasingly being recognized as the hepatic manifestation of metabolic syndrome that can lead to cardiovascul...