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Transitional dendritic cells: identifying the origin and role of a novel innate immune population during viral infection
ABSTRACT Plasmacytoid dendritic cells (pDCs) are a unique subset of innate immune cells capable of multiple functions essential for antiviral responses, including type I interferon...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis. CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
Despite advances in colorectal cancer (CRC) treatment and early detection, the burden of CRC on African Americans (AAs) remains high. AAs have the highest incidence of CRC among al...
Transitional dendritic cells: identifying the origin and role of a novel innate immune population during viral infection
ABSTRACT Plasmacytoid dendritic cells (pDCs) are a unique subset of innate immune cells capable of multiple functions essential for antiviral responses, including type I interferon...
Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk
PROJECT SUMMARY/ABSTRACT Antipsychotic-induced weight gain (AIWG) is of significant public health importance in mentally ill populations, potentially addressable with personalized,...
Computational Methods for Assembling Multiple RNA-seq Samples
PROJECT SUMMARY / ABSTRACT RNA-seq has become standard routine in many biological and biomedical experiments to study gene activities. A very first step of RNA-seq analysis is usua...
Transitional dendritic cells: identifying the origin and role of a novel innate immune population during viral infection
ABSTRACT Plasmacytoid dendritic cells (pDCs) are a unique subset of innate immune cells capable of multiple functions essential for antiviral responses, including type I interferon...
Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) accounts for nearly 31,000 deaths annually in the United States alone. Factors that epigenetically silence an HCC tumor suppressor ge...
Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression. In fact, our analysis of the cancer genome atlas (T...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis. CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis. CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Genetic interactions and multifactorial genetics mediate myocardial regeneration
PROJECT SUMMARY/ABSTRACT Dogma in the cardiovascular field argues that the adult mammalian heart is essentially non-regenerative and that this failure to regenerate is primarily at...
Multiplexed Detection of Mosquito-Borne Viruses at the Point-of-Care
Project Summary Dengue virus (DENV), Zika virus (ZIKV), Chikungunya virus (CHIKV), and Mayaro virus (MAYV) are all mosquito-borne RNA viruses.They are public health concerns becaus...
The rectal microbiome and incident rectal sexually transmitted infections
In men who have sex with men (MSM) rectal sexually transmitted infections (STIs) including Neisseria gonorrhoea (NG) and Chlamydia trachomatis (CT) are of great concern.Rectal NG/C...
Developing broad-spectrum therapeutics against C. difficile toxins
Project Summary Clostridioides difficile (C. difficile) is a major opportunistic pathogen that colonizes the colon when normal gut microbiota is disrupted.The large protein toxin T...
BCL11B activation as an approach for enhancing the efficacy of immunotherapy
Our goal is to investigate overexpression of the T-lineage transcription factor (TF) BCL11B as a novel strategy to enhance: 1) T-cell reconstitution after allogeneic hematopoietic...
Administrative Supplement for the HEROS Study Serology
The COVID-19 pandemic is the most important health challenge to the US population within a century.Most epidemiological data have focused on cases that resulted in severe respirato...
Project 3 - Ex vivo immune profiling of dengue viruses and vaccines
The COVID-19 pandemic is the most important health challenge to the US population within a century.Most epidemiological data have focused on cases that resulted in severe respirato...
Genetic interactions and multifactorial genetics mediate myocardial regeneration
PROJECT SUMMARY/ABSTRACT Dogma in the cardiovascular field argues that the adult mammalian heart is essentially non-regenerative and that this failure to regenerate is primarily at...
Developing broad-spectrum therapeutics against C. difficile toxins
Project Summary Clostridioides difficile (C. difficile) is a major opportunistic pathogen that colonizes the colon when normal gut microbiota is disrupted. The large protein toxin...