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99,167 grants found
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Genetic interactions and multifactorial genetics mediate myocardial regeneration
PROJECT SUMMARY/ABSTRACT Dogma in the cardiovascular field argues that the adult mammalian heart is essentially non-regenerative and that this failure to regenerate is primarily at...
Multiplexed Detection of Mosquito-Borne Viruses at the Point-of-Care
Project Summary Dengue virus (DENV), Zika virus (ZIKV), Chikungunya virus (CHIKV), and Mayaro virus (MAYV) are all mosquito-borne RNA viruses. They are public health concerns becau...
The rectal microbiome and incident rectal sexually transmitted infections
In men who have sex with men (MSM) rectal sexually transmitted infections (STIs) including Neisseria gonorrhoea (NG) and Chlamydia trachomatis (CT) are of great concern. Rectal NG/...
BCL11B activation as an approach for enhancing the efficacy of immunotherapy
Our goal is to investigate overexpression of the T-lineage transcription factor (TF) BCL11B as a novel strategy to enhance: 1) T-cell reconstitution after allogeneic hematopoietic...
Genetic interactions and multifactorial genetics mediate myocardial regeneration
PROJECT SUMMARY/ABSTRACT Dogma in the cardiovascular field argues that the adult mammalian heart is essentially non-regenerative and that this failure to regenerate is primarily at...
Developing broad-spectrum therapeutics against C. difficile toxins
Project Summary Clostridioides difficile (C. difficile) is a major opportunistic pathogen that colonizes the colon when normal gut microbiota is disrupted. The large protein toxin...
Multiplexed Detection of Mosquito-Borne Viruses at the Point-of-Care
Project Summary Dengue virus (DENV), Zika virus (ZIKV), Chikungunya virus (CHIKV), and Mayaro virus (MAYV) are all mosquito-borne RNA viruses. They are public health concerns becau...
Genetic interactions and multifactorial genetics mediate myocardial regeneration
PROJECT SUMMARY/ABSTRACT Dogma in the cardiovascular field argues that the adult mammalian heart is essentially non-regenerative and that this failure to regenerate is primarily at...
BCL11B activation as an approach for enhancing the efficacy of immunotherapy
Our goal is to investigate overexpression of the T-lineage transcription factor (TF) BCL11B as a novel strategy to enhance: 1) T-cell reconstitution after allogeneic hematopoietic...
Genetic interactions and multifactorial genetics mediate myocardial regeneration
PROJECT SUMMARY/ABSTRACT Dogma in the cardiovascular field argues that the adult mammalian heart is essentially non-regenerative and that this failure to regenerate is primarily at...
Developing broad-spectrum therapeutics against C. difficile toxins
Project Summary Clostridioides difficile (C. difficile) is a major opportunistic pathogen that colonizes the colon when normal gut microbiota is disrupted. The large protein toxin...
BCL11B activation as an approach for enhancing the efficacy of immunotherapy
Our goal is to investigate overexpression of the T-lineage transcription factor (TF) BCL11B as a novel strategy to enhance: 1) T-cell reconstitution after allogeneic hematopoietic...
Mechanisms of leukemogenesis in Down syndrome
PROJECT SUMMARY This is a competitive renewal of our NCI funded grant to study the contributions of trisomy 21 to hematologic malignancies.Children with Down syndrome (DS), who hav...
Genetic interactions and multifactorial genetics mediate myocardial regeneration
PROJECT SUMMARY/ABSTRACT Dogma in the cardiovascular field argues that the adult mammalian heart is essentially non-regenerative and that this failure to regenerate is primarily at...
Multiplexed Detection of Mosquito-Borne Viruses at the Point-of-Care
Project Summary Dengue virus (DENV), Zika virus (ZIKV), Chikungunya virus (CHIKV), and Mayaro virus (MAYV) are all mosquito-borne RNA viruses. They are public health concerns becau...
Genetic interactions and multifactorial genetics mediate myocardial regeneration
PROJECT SUMMARY/ABSTRACT Dogma in the cardiovascular field argues that the adult mammalian heart is essentially non-regenerative and that this failure to regenerate is primarily at...
Inflammatory cascades disrupt Treg function through epigenetic mechanisms
PROJECT SUMMARY/ABSTRACT CD4+FOXP3+lymphocytes are expanded within the intestinal inflammatory lesion of Crohn’s disease (CD); however, ongoing inflammation belies presumed anti-in...
Th1/Th17 Immune Regulation in Severe Allergic Asthma
Project Summary/Abstract This is the resubmission of a grant entitled “Th1/Th17 Immune Regulation in Severe Allergic Asthma” (1 RO3 AI163794-01) which focuses on the mechanism of d...
WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity
PROJECT SUMMARY Of the greater than 350 Primary Immunodeficiency Diseases (PID) in humans that have been identified to date, the molecular basis of a significant number (~100) of P...
Transcriptional control of NK cell metabolism
Project Summary Natural killer (NK) cells comprise an important arm of the host innate immune system that detects and eliminates virus-infected cells. Newborns and immune-compromis...