Browse All Grants
99,167 grants found
Showing 95,781 – 95,800 of 99,167 grants
Nannocystin Reagents to Elucidate the Role of Elongation Factor 1a in Apoptosis
Project Summary Nannocystin reagents will be used to interrogate the role of the protein elongation factor 1A in apoptosis of cancer cells. Nannocystins are small molecule natural...
Role of Erbb3 kinase activity in colorectal tumorigenesis.
ABSTRACT Immunotherapy is the standard of care and an effective treatment for colorectal cancers with deficient mismatch repair proteins (dMMR). The deficiency contributes to high...
Visualizing cell dormancy in a Her2 Crainbow model of breast cancer metastasis
Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-029. Dr. Snyder’s OMF R01, “Visualizing tumor heterogenei...
Characterizing the role of cellular differentiation in productive papillomavirus amplification
Project Summary/Abstract Human papillomavirus (HPV) infections are responsible for a staggering 5% of all cancers worldwide. In the developed world, these infections cause an incre...
Pro-Drug Enolase Inhibitors in Precision Oncology
ABSTRACT.Genomic deletions of major tumor suppressor genes are frequent events in cancer yet presently remain therapeutically unactionable for the purpose of precision oncology.Our...
Biomechanical Markers of PTOA after ACL Reconstruction and Meniscal Resection
Project Summary An estimated 120,000 anterior cruciate ligament (ACL) tears are repaired surgically on an annual basis in the United States.Surgical repair stabilizes the ACL-defic...
Synthetic rocaglates as promising therapeutic agents for aggressive hematological malignancies
Project Summary/Abstract Despite the significant advances in therapy development, a large proportion of hematological malignancies, especially the aggressive types remain incurable...
VTEU Supplement
Project Summary/Abstract The University of Maryland School of Medicine (UMSOM) Center for Vaccine Development and Global Health (CVD) has been an established VTEU site since 1974.T...
Impact of Prescription Caps on Health Outcomes in People Infected with HIV
PROJECT SUMMARY The availability of contemporary antiretroviral therapy (ART) has changed infection into a manageable chronic disease for people living with HIV (PLWH) who have acc...
Regulation of Voltage-gated Proton Channel
Abstract The voltage-gated Hv1 proton channel is a member of voltage-gated ion channel family, it plays a key role in the acid extrusion from excitable and non-excitable cells and...
Anti-inflammatory functions for non-transcriptional IRF3
Project Summary/Abstract The innate immune response is the first line of defense against microbial infection. Virus infection causes rapid induction of interferon (IFN) and IFN-ind...
Characterizing the role of cellular differentiation in productive papillomavirus amplification
Project Summary/Abstract Human papillomavirus (HPV) infections are responsible for a staggering 5% of all cancers worldwide. In the developed world, these infections cause an incre...
Biomechanical Markers of PTOA after ACL Reconstruction and Meniscal Resection
Project Summary An estimated 120,000 anterior cruciate ligament (ACL) tears are repaired surgically on an annual basis in the United States. Surgical repair stabilizes the ACL-defi...
Pro-Drug Enolase Inhibitors in Precision Oncology
ABSTRACT. Genomic deletions of major tumor suppressor genes are frequent events in cancer yet presently remain therapeutically unactionable for the purpose of precision oncology. O...
Synthetic rocaglates as promising therapeutic agents for aggressive hematological malignancies
Project Summary/Abstract Despite the significant advances in therapy development, a large proportion of hematological malignancies, especially the aggressive types remain incurable...
Implementing Vaccine and Treatment Evaluation Unit (VTEU) Clinical Site
Project Summary/Abstract The University of Maryland School of Medicine (UMSOM) Center for Vaccine Development and Global Health (CVD) has been an established VTEU site since 1974....
Pro-Drug Enolase Inhibitors in Precision Oncology
ABSTRACT. Genomic deletions of major tumor suppressor genes are frequent events in cancer yet presently remain therapeutically unactionable for the purpose of precision oncology. O...
Regulation of Voltage-gated Proton Channel
Abstract The voltage-gated Hv1 proton channel is a member of voltage-gated ion channel family, it plays a key role in the acid extrusion from excitable and non-excitable cells and...
Anti-inflammatory functions for non-transcriptional IRF3
Project Summary/Abstract The innate immune response is the first line of defense against microbial infection. Virus infection causes rapid induction of interferon (IFN) and IFN-ind...
Regulation of Voltage-gated Proton Channel
Abstract The voltage-gated Hv1 proton channel is a member of voltage-gated ion channel family, it plays a key role in the acid extrusion from excitable and non-excitable cells and...