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99,167 grants found
Showing 96,041 – 96,060 of 99,167 grants
Targeting immune suppressive microenvironment in ATC
PROJECT SUMMARY/ABSTRACT Patients with anaplastic thyroid cancer (ATC) have a median survival of 6 months.Chemotherapy in combination with surgery and radiation may modestly extend...
Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants
Among load-bearing implants, total hip arthroplasty (THA) is probably the most clinically successful intervention. CoCrMo alloy, a wear resistant material of choice, is typically u...
WildCam: A Privacy Conscious Wearable Eating Detection Camera People will Actually Wear in the Wild
Project Summary Behavioral interventions for weight loss include self-monitoring and self-report of diet. However, few people adhere to self-monitoring because they believe it will...
Effects of cell-type specific brain stimulation in Alzheimer's model mice
Project Abstract. Alzheimer?s disease is the most common neurodegenerative disorder and the leading cause of dementia in the elderly.Aberrant brain activity has become recognized a...
Mitochondria targeting for Alzheimer's Disease
PROJECT SUMMARY Decreased energy metabolism is an invariant feature of the brains of Alzheimer?s disease (AD) patients, yet the specific use of pharmacologic strategies to manipula...
Role of gasderminD in ganglion cell dysfunction and injury
In primary glaucoma, ocular hypertension (OHT) stress triggers a neurotoxic cascade leading to selective death of retinal ganglion cells (RGC).However, the molecular mechanism tran...
Develop an Artificial Intelligence-powered Smartphone App AICaries for Caries Detection in Children
Project Summary Early childhood caries (ECC) is the most common chronic childhood disease, with nearly 1.8 billion new cases per year globally.ECC afflicts approximately 55% of low...
The role of lung lipofibroblasts in alveolar differentiation
Abstract A complication of preterm birth is underdeveloped lungs that lack surfactant and adequate gas exchange due to immature alveoli. Although recent advances have been made, th...
A Single Ascending Dose / Multiple Ascending Dose Phase I study of the GSM 776890 in healthy normal subjects
Scientific Abstract AD is currently a huge health problem that imposes a severe social and economic burden; in the absence of an effective disease modifying treatment it is project...
Drug overdose out-of-hospital cardiac arrest events in the United States: Insights from a large data registry
PROJECT SUMMARY Drug overdose out-of-hospital cardiac arrest (OD-OHCA) is a serious and growing public health threat that is wholly understudied.Currently, we lack a broadly-repres...
Re-purposing beta-blockers to improve chemotherapy response
ABSTRACT Metastatic tumors often develop chemoresistance, which makes chemotherapy ineffective.We have exciting evidence that beta-blockers, which are widely used cardiac drugs, ca...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...
A Chemical Strategy of Developing Resistance-Proof, Immune-Friendly Drugs
Clever synthetic strategies have been used to develop highly potent drugs such as antibiotics and chemotherapeutic agents, but concurrently bacteria and cancer cells have also deve...
Role of Erbb3 kinase activity in colorectal tumorigenesis.
The overarching goals of this proposal are to determine if Erbb3 kinase plays a critical role in colorectal tumorigenesis and to test if colorectal cancer with oncogenic Erbb3 muta...
The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
Project Summary Identification of molecular pathways that are preferentially employed and relied upon by cancer cells compared to normal cells is key to designing novel personalize...
Harnessing Glycoproteomics and Glycomics to Understand Cardiac Biology and Disease
ABSTRACT Our research program develops and applies innovative mass spectrometry technologies, bioinformatics tools, and methodologies to transform our understanding of cell surface...
Focal nerve fiber layer reflectance analysis for glaucoma evaluation
PROJECT SUMMARY Glaucoma is a leading cause of blindness, and effective glaucoma management requires early detection.Nerve fiber layer (NFL) thickness measurement by optical cohere...
Tissue factor-dependent coagulation in thrombosis and immune responses
Tissue factor (TF) is a transmembrane protein that functions as a high-affinity receptor for factor (F)VII and FVIIa. The TF-FVIIa complex is the primary initiator of coagulation a...
Central mechanisms of itch transmission
Abstract Chronic itch is an unmet medical problem associated with numerous skin, immune, and nervous diseases. An imbalance of excitatory and inhibitory transmission of itch may co...
The impact of the environment on sensorimotor cortex in rats: Functional organization, connections and behavior
The emergence of the neocortex and its capacity to be shaped by early sensory and motor experience is the hallmark of mammalian brain evolution.This remarkable plasticity allows th...